KIAA1462, a coronary artery disease associated gene, is a candidate gene for late onset Alzheimer disease in APOE carriers

PloS One
Deborah G MurdockJ L Haines

Abstract

Alzheimer disease (AD) is a devastating neurodegenerative disease affecting more than five million Americans. In this study, we have used updated genetic linkage data from chromosome 10 in combination with expression data from serial analysis of gene expression to choose a new set of thirteen candidate genes for genetic analysis in late onset Alzheimer disease (LOAD). Results in this study identify the KIAA1462 locus as a candidate locus for LOAD in APOE4 carriers. Two genes exist at this locus, KIAA1462, a gene associated with coronary artery disease, and "rokimi", encoding an untranslated spliced RNA The genetic architecture at this locus suggests that the gene product important in this association is either "rokimi", or a different isoform of KIAA1462 than the isoform that is important in cardiovascular disease. Expression data suggests that isoform f of KIAA1462 is a more attractive candidate for association with LOAD in APOE4 carriers than "rokimi" which had no detectable expression in brain.

References

Oct 20, 1995·Science·V E VelculescuK W Kinzler
Aug 18, 1995·Science·E Levy-LahadG D Schellenberg
Dec 15, 1994·American Journal of Medical Genetics·S E Hodge
Mar 1, 1997·Archives of General Psychiatry·A L BergemE Kringlen
Feb 5, 1999·Human Molecular Genetics·P KehoeM J Owen
Aug 7, 1999·Human Heredity·A BhatJ Ott
May 29, 2000·American Journal of Human Genetics·E R MartinN L Kaplan
Dec 13, 2000·Experimental Gerontology·M A Pericak-VanceJ L Haines
Nov 28, 2001·Alzheimer Disease and Associated Disorders·L E HebertD A Evans
Jan 17, 2002·Genetic Epidemiology·K D SiegmundW J Gauderman
Jun 5, 2002·Genome Research·W James KentDavid Haussler
Dec 20, 2002·Human Molecular Genetics·Deborah BlackerUNKNOWN NIMH Genetics Initiative Alzheimer's Disease Study Group
Feb 5, 2003·Human Molecular Genetics·Lindsay A FarrerClinton T Baldwin
Aug 20, 2003·Archives of Neurology·Liesi E HebertDenis A Evans
Oct 11, 2003·American Journal of Human Genetics·Eden R MartinNorman L Kaplan
Oct 15, 2003·Genetic Epidemiology·E R MartinE R Hauser
Jul 21, 2004·Annals of Internal Medicine·Yiqing SongSimin Liu
Aug 7, 2004·Bioinformatics·J C BarrettM J Daly
Mar 29, 2006·Proceedings of the National Academy of Sciences of the United States of America·Robert W MahleyYadong Huang
Nov 18, 2006·BMC Bioinformatics·Yi-Ju LiJohn R Gilbert
Jun 19, 2007·Human Mutation·Xueying LiangJonathan L Haines
Sep 20, 2007·JAMA : the Journal of the American Medical Association·Anna M BennetJohn Danesh
Oct 11, 2008·PLoS Genetics·Jean-Baptiste VeyrierasJonathan K Pritchard
Feb 26, 2009·Human Mutation·Xueying LiangJonathan L Haines
Sep 19, 2009·PLoS Genetics·Reshmi ChowdhuryVivian G Cheung
May 6, 2010·Journal of Alzheimer's Disease : JAD·Jose Viña, Ana Lloret
May 18, 2010·Alzheimer Disease and Associated Disorders·Ulrika K ErikssonNancy L Pedersen
Nov 23, 2010·European Heart Journal·Jeanette ErdmannHeribert Schunkert
Mar 8, 2011·Nature Genetics·UNKNOWN Coronary Artery Disease (C4D) Genetics Consortium
Sep 3, 2011·Biochemical and Biophysical Research Communications·Masaya AkashiMikio Furuse
Apr 10, 2012·Progress in Molecular Biology and Translational Science·Lars Bertram, Rudolph E Tanzi
Jan 1, 2012·Scientifica·Robert C Barber

❮ Previous
Next ❯

Citations

Aug 17, 2018·BioMed Research International·Ankit TandonRajnish Kumar Chaturvedi
Feb 6, 2017·Journal of Molecular Neuroscience : MN·Yu-Jie LaiGuo-Jun Chen
Dec 30, 2017·Experimental and Therapeutic Medicine·Lu LiuGuo-Jun Chen
Oct 22, 2020·Heliyon·Manabu ShigeokaMasaya Akashi

❮ Previous
Next ❯

Methods Mentioned

BETA
Genotyping
PCR

Software Mentioned

SpectroTYPER Analyzer
Haploview
eQTL Browser
Sequenom SpectroDESIGNER
SpectraAQUIRE
UCSC genome browser
Aperture
FASTLINK
SpectroCALLER
LDSelect

Related Concepts

Related Feeds

Alzheimer's Disease: Genetics

Alzheimer's disease is a neurodegenerative disease. Discover genetic and epigenetic aspects of Alzheimer’s disease, including genetic markers and genomic structural variations with this feed.

Cardiovascular Inflammation

Inflammation plays a significant role in the development of cardiovascular diseases, an understanding of these endogenous processes is critical for evaluating the risks and potential treatment strategies. Discover the latest research on cardiovascular inflammation here.

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

Alzheimer's Disease: RNA Regulation

RNA regulation involves several mechanisms that are used by cells to decrease or increase the production of RNA. Disruption of RNA regulatory processes has been associated with Alzheimer's disease (AD). Here are the latest discoveries pertaining to RNA regulation and AD.

Antisense Oligonucleotides: ND

This feed focuses on antisense oligonucleotide therapies such as Inotersen, Nusinursen, and Patisiran, in neurodegenerative diseases including amyotrophic lateral sclerosis.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.