KIAA1718 is a histone demethylase that erases repressive histone methyl marks

Genes to Cells : Devoted to Molecular & Cellular Mechanisms
Atsushi YokoyamaShigeaki Kato

Abstract

The methylation states of histone lysine residues are regarded as significant epigenetic marks governing transcriptional regulation. A number of histone demethylases containing a jumonji C (JmjC) domain have been recognized; however, their properties remain to be investigated. Here, we show that KIAA1718, a PHF2/PHF8 subfamily member, possesses histone demethylase activity specific for H3K9 and H3K27, transcriptionally repressive histone marks. Biochemical purification of the KIAA1718 interactants reveals that KIAA1718 forms complexes with several factors including KAP1, a transcriptional co-activator. Consistent with these findings, KIAA1718 shows a transcriptional activation function in the chromatin context. Thus, our study identifies KIAA1718 as a histone demethylase for repressive methyl marks and shows that it is involved in transcriptional activation.

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Citations

Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·Sebastian CanovasPablo J Ross
Sep 25, 2012·Nucleic Acids Research·Marloes L de GrooteMarianne G Rots
Dec 21, 2010·Journal of Molecular Biology·John R HortonXiaodong Cheng
Jan 10, 2012·Journal of Molecular Biology·Anup K UpadhyayXiaodong Cheng
May 10, 2011·Molecular Cell·Frank W SchmitgesNicolas H Thomä
Jun 29, 2011·Biochemical and Biophysical Research Communications·Atsushi YokoyamaShigeaki Kato
May 7, 2016·Current Opinion in Genetics & Development·Kelly Marie ArcipowskiPanagiotis Ntziachristos
Dec 12, 2017·Biochemistry Research International·Atsushi YokoyamaAkira Sugawara

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