Kidins220/ARMS is a novel modulator of short-term synaptic plasticity in hippocampal GABAergic neurons.

PloS One
J Scholz-StarkePietro Baldelli

Abstract

Kidins220 (Kinase D interacting substrate of 220 kDa)/ARMS (Ankyrin Repeat-rich Membrane Spanning) is a scaffold protein highly expressed in the nervous system. Previous work on neurons with altered Kidins220/ARMS expression suggested that this protein plays multiple roles in synaptic function. In this study, we analyzed the effects of Kidins220/ARMS ablation on basal synaptic transmission and on a variety of short-term plasticity paradigms in both excitatory and inhibitory synapses using a recently described Kidins220 full knockout mouse. Hippocampal neuronal cultures prepared from embryonic Kidins220(-/-) (KO) and wild type (WT) littermates were used for whole-cell patch-clamp recordings of spontaneous and evoked synaptic activity. Whereas glutamatergic AMPA receptor-mediated responses were not significantly affected in KO neurons, specific differences were detected in evoked GABAergic transmission. The recovery from synaptic depression of inhibitory post-synaptic currents in WT cells showed biphasic kinetics, both in response to paired-pulse and long-lasting train stimulation, while in KO cells the respective slow components were strongly reduced. We demonstrate that the slow recovery from synaptic depression in WT cells is ...Continue Reading

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Citations

Mar 26, 2016·Frontiers in Cellular Neuroscience·Joachim Scholz-Starke, Fabrizia Cesca
Oct 19, 2019·Cell Death and Differentiation·Fanny JaudonFabrizia Cesca
Jun 4, 2015·The Journal of Biological Chemistry·Fabrizia CescaJoachim Scholz-Starke
May 9, 2012·Journal of Cell Science·Veronika E NeubrandGiampietro Schiavo

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Software Mentioned

Leica LAS AF
Kidins220
ImageJ
FitMaster
PatchMaster
Synaptosoft
Mini Analysis
Adobe Photoshop

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