Kidney after nonrenal transplantation-the impact of alemtuzumab induction.

Transplantation
Ron ShapiroThomas E Starzl

Abstract

Calcineurin inhibitor nephrotoxicity in nonrenal allograft recipients can lead to end-stage renal disease and the need for kidney transplantation. We sought to evaluate the role of alemtuzumab induction in this population. We evaluated 144 patients undergoing kidney transplantation after nonrenal transplantation between May 18, 1998, and October 8, 2007. Seventy-two patients transplanted between January 15, 2003, and October 8, 2007, received alemtuzumab induction and continued their pretransplant immunosuppression. Seventy-two patients transplanted between May 18, 1998, and July 21, 2007, did not receive alemtuzumab induction, but received additional steroids and maintenance immunosuppression. Donor and recipient demographics were comparable. Overall, 1- and 3-year patient survival and renal function were comparable between the two groups. One- and 3-year graft survival was 93.0% and 75.3% in the alemtuzumab group and 83.3% and 68.7% in the no alemtuzumab group, respectively (P=0.051). The incidence of acute rejection was lower in the alemtuzumab group, 15.3%, than in the no alemtuzumab group, 41.7% (P=0.0001). The incidence of delayed graft function was lower in the alemtuzumab group, 9.7%, than in the no alemtuzumab group, 2...Continue Reading

References

Aug 16, 2002·Medical Oncology·Herman Waldmann
Jun 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Stuart J KnechtleHans W Sollinger
Sep 5, 2003·The New England Journal of Medicine·Akinlolu O OjoRobert M Merion
Apr 5, 2005·Journal of the American College of Surgeons·Ron ShapiroThomas E Starzl
Oct 21, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Bijan EghtesadThomas E Starzl
Aug 8, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H P TanR Shapiro

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Citations

Nov 26, 2010·Immunotherapy·Annemarie WeissenbacherStefan Schneeberger
May 20, 2014·Annals of Plastic Surgery·Gerald T GrantChad R Gordon
Mar 30, 2010·Transplant International : Official Journal of the European Society for Organ Transplantation·Benjamin Grable, Tetsuro Sakai
Sep 4, 2012·Current Opinion in Organ Transplantation·Christina Nguyen, Ron Shapiro
Sep 27, 2018·Transplantation Direct·Chethan M PuttarajappaHiroshi Sogawa

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