Kidney Biopsy Findings in Patients with COVID-19.

Journal of the American Society of Nephrology : JASN
Satoru KudoseVivette D D'Agati

Abstract

Coronavirus disease 2019 (COVID-19) is thought to cause kidney injury by a variety of mechanisms. To date, pathologic analyses have been limited to patient reports and autopsy series. We evaluated biopsy samples of native and allograft kidneys from patients with COVID-19 at a single center in New York City between March and June of 2020. We also used immunohistochemistry, in situ hybridization, and electron microscopy to examine this tissue for presence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The study group included 17 patients with COVID-19 (12 men, 12 black; median age of 54 years). Sixteen patients had comorbidities, including hypertension, obesity, diabetes, malignancy, or a kidney or heart allograft. Nine patients developed COVID-19 pneumonia. Fifteen patients (88%) presented with AKI; nine had nephrotic-range proteinuria. Among 14 patients with a native kidney biopsy, 5 were diagnosed with collapsing glomerulopathy, 1 was diagnosed with minimal change disease, 2 were diagnosed with membranous glomerulopathy, 1 was diagnosed with crescentic transformation of lupus nephritis, 1 was diagnosed with anti-GBM nephritis, and 4 were diagnosed with isolated acute tubular injury. The three allograft specim...Continue Reading

References

Jul 3, 2009·The New England Journal of Medicine·Laurence H BeckDavid J Salant
Mar 6, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Glen S MarkowitzVivette D D'Agati
Jul 28, 2010·The New England Journal of Medicine·Vadim PedchenkoBilly G Hudson
Dec 15, 2011·The Journal of Molecular Diagnostics : JMD·Fay WangYuling Luo
May 6, 2016·Journal of the American Society of Nephrology : JASN·Ibrahim BatalVivette D D'Agati
Jan 20, 2017·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P F HalloranK S Famulski
May 19, 2017·Clinical Journal of the American Society of Nephrology : CJASN·Stephen P McAdoo, Charles D Pusey
Feb 5, 2019·Kidney International·Hae-Yoon Grace ChoungVivette D D'Agati
Mar 25, 2020·Kidney International·Saraladevi NaickerVivekanand Jha
Apr 1, 2020·The New England Journal of Medicine·Muthiah VaduganathanScott D Solomon
Apr 6, 2020·Kidney International·Yichun ChengGang Xu
Apr 16, 2020·KI Reports·Christopher P LarsenMoh'd A Sharshir
Apr 30, 2020·Journal of the American Society of Nephrology : JASN·Guangchang PeiGang Xu
May 6, 2020·Journal of the American Society of Nephrology : JASN·Daniel BatlleUNKNOWN COVID-19 and ACE2 in Cardiovascular, Lung, and Kidney Working Group
May 7, 2020·Journal of the American Society of Nephrology : JASN·Evan A FarkashJeffrey M Jentzen
May 14, 2020·The New England Journal of Medicine·Victor G PuellesTobias B Huber
May 14, 2020·The New England Journal of Medicine·Meghan E SiseEugene P Rhee
May 15, 2020·Cell Host & Microbe·Zhuo ZhouJianwei Wang
May 18, 2020·Kidney International·Jamie S HirschUNKNOWN Northwell Nephrology COVID-19 Research Consortium
May 22, 2020·Kidney International·Sara E Miller, John K Brealey
May 22, 2020·Kidney International·Edward CalomeniTibor Nadasdy
May 22, 2020·Kidney International·Sébastien KisslingFadi Fakhouri
May 31, 2020·Kidney International·Sébastien KisslingFadi Fakhouri
May 31, 2020·Kidney International·François GaillardEric Daugas

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Citations

Oct 3, 2020·Case Reports in Nephrology·Yannick M NlanduFrançois B Lepira
Sep 25, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Edward D Siew, Bethany C Birkelo
Oct 8, 2020·Journal of Clinical Pathology·Camila Barbosa OliveiraPaula Sandrin-Garcia
Oct 21, 2020·Nature Reviews. Nephrology·Luca PericoGiuseppe Remuzzi
Dec 4, 2020·Journal of Intensive Care Medicine·Jingyuan XuSean M Bagshaw
Dec 5, 2020·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Suyuan PengMing-Hui Zhao
Dec 9, 2020·Journal of the American Society of Nephrology : JASN·David J Friedman
Dec 16, 2020·Archives of Physiology and Biochemistry·Manoj KhokharPraveen Sharma
Dec 20, 2020·The FEBS Journal·Rohan Goyal, Pravin C Singhal
Nov 21, 2020·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Samih H NasrSanjeev Sethi
Jan 10, 2021·BMC Nephrology·Katarzyna SzajekPhilipp Grosse
Jan 20, 2021·American Journal of Physiology. Renal Physiology·Licy L Yanes CardozoDamian G Romero
Jan 23, 2021·International Journal of Molecular Sciences·Giovanni ZarrilliMatteo Fassan
Jan 28, 2021·Cell·Xiu NieTiannan Guo
Jan 28, 2021·Nephrology·Cigdem YildirimMurat Dizbay
Oct 15, 2020·Journal of the American Society of Nephrology : JASN·Shaza KhanMark A Knepper
Nov 21, 2020·Journal of the American Society of Nephrology : JASN·Aneesha A ShettySusan E Quaggin
Jan 11, 2021·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Dennis G MoledinaF Perry Wilson
Oct 29, 2020·BMC Nephrology·Sam KantBernard G Jaar
Oct 30, 2020·Journal of the American Society of Nephrology : JASN·Ron Wald, Sean M Bagshaw
Jan 5, 2021·Clinical Kidney Journal·Valentin MayetHélène François
Feb 16, 2021·Frontiers in Immunology·Frederick PfisterChristoph Daniel
Dec 23, 2020·Transplantation·Laila A VianaJosé Medina-Pestana
Feb 5, 2021·Nature Metabolism·Janis A MüllerAlexander Kleger
Dec 15, 2020·Advances in Chronic Kidney Disease·Jia H NgKenar D Jhaveri
Feb 28, 2021·Journal of the American Society of Nephrology : JASN·Paul M Palevsky
Feb 27, 2021·Frontiers in Medicine·Welder ZamonerDaniela Ponce
Nov 7, 2020·Journal of the American Society of Nephrology : JASN·Jordan L Rosenstock, Vanesa Bijol
Mar 7, 2021·Journal of Clinical Medicine·Luis Sanchez-RussoPaolo Cravedi
Feb 23, 2021·KI Reports·Sanjeev SethiFernando C Fervenza
Mar 12, 2021·Seminars in Dialysis·Jacob S StevensSumit Mohan
Mar 9, 2021·Frontiers in Medicine·Yuanyuan ChenZhongji Meng
Mar 23, 2021·Journal of Nephrology·Hong XuMaria Eriksdotter
Mar 24, 2021·Nature Medicine·Ani NalbandianElaine Y Wan
Feb 13, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Sophie FerlicotUNKNOWN AP-HP/Universities/Inserm COVID-19 research collaboration
Feb 16, 2021·The Journal of Pathology·Larissa E van EijkHarry van Goor
Mar 27, 2021·Current Opinion in Nephrology and Hypertension·Leslie A BruggemanJohn F O'Toole
Mar 27, 2021·Current Opinion in Nephrology and Hypertension·Kelly D Smith, Shreeram Akilesh

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