Kidney dysfunction at the time of intracerebral hemorrhage is associated with increased in-hospital mortality: a retrospective observational cohort study

Neurological Research
Denise H RhoneyPeter Whittaker


Renal dysfunction has been implicated as a risk factor for adverse outcomes after numerous cardiovascular events including stroke. However, most of the stroke studies have focused on long-term results and have primarily examined ischemic stroke. Therefore, we aimed to determine if renal dysfunction was associated with increased initial in-hospital mortality after intracerbral hemorrhage (ICH). Our retrospective, observational, cohort chart review evaluated the relationship between in-hospital mortality after ICH and renal function, assessed from admission estimated glomerular filtration rate (eGFR), calculated using the abbreviated modification of diet in renal disease equation, in 101 consecutive cases. Survivors had higher admission eGFRs than those who died (88 ± 37 versus 59 ± 33 ml/minute/1.73 m(2); P<0.001). Similarly, mortality was higher in patients with eGFR <90 versus those >90 ml/minute/1.73 m(2) (40% versus 15%; P = 0.009). Univariate analysis indicated that in-hospital death was associated with intraventricular hemorrhage, ICH volume, age, eGFR <90 ml/minute/1.73 m(2), and admission values of serum creatinine, and blood urea nitrogen (P<0·05). Multivariable logistic regression (controlled for confounding variables)...Continue Reading


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Related Concepts

Cerebral Hemorrhage
Glomerular Filtration Rate
Kidney Diseases
Retrospective Studies
Incidence Studies
Logistic Regression
Survival Analysis
Hospital Mortality
Observation in Research

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