Kidney dysfunction at the time of intracerebral hemorrhage is associated with increased in-hospital mortality: a retrospective observational cohort study

Neurological Research
Denise H RhoneyPeter Whittaker

Abstract

Renal dysfunction has been implicated as a risk factor for adverse outcomes after numerous cardiovascular events including stroke. However, most of the stroke studies have focused on long-term results and have primarily examined ischemic stroke. Therefore, we aimed to determine if renal dysfunction was associated with increased initial in-hospital mortality after intracerbral hemorrhage (ICH). Our retrospective, observational, cohort chart review evaluated the relationship between in-hospital mortality after ICH and renal function, assessed from admission estimated glomerular filtration rate (eGFR), calculated using the abbreviated modification of diet in renal disease equation, in 101 consecutive cases. Survivors had higher admission eGFRs than those who died (88 ± 37 versus 59 ± 33 ml/minute/1.73 m(2); P<0.001). Similarly, mortality was higher in patients with eGFR <90 versus those >90 ml/minute/1.73 m(2) (40% versus 15%; P = 0.009). Univariate analysis indicated that in-hospital death was associated with intraventricular hemorrhage, ICH volume, age, eGFR <90 ml/minute/1.73 m(2), and admission values of serum creatinine, and blood urea nitrogen (P<0·05). Multivariable logistic regression (controlled for confounding variables)...Continue Reading

References

Feb 1, 1991·Journal of Internal Medicine·P J Friedman
Apr 3, 2001·Stroke; a Journal of Cerebral Circulation·J C HemphillS C Johnston
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Ronald S MacWalterRouling Chen
Oct 19, 2007·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·T Hojs FabjanB Pecovnik Balon
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
May 18, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Bruce OvbiageleJeffrey L Saver

Citations

Oct 19, 2013·The Psychiatric Quarterly·Peter ManuChristoph U Correll
Jun 12, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Khai P NgCharles J Ferro
Nov 6, 2012·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Shawna CuttingShyam Prabhakaran
Mar 14, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Anne RowatMartin Dennis
Apr 9, 2014·Current Opinion in Nephrology and Hypertension·Nisha BansalAlan S Go

Related Concepts

Cerebral Hemorrhage
Glomerular Filtration Rate
Kidney Diseases
Retrospective Studies
Incidence Studies
Logistic Regression
Survival Analysis
Hospital Mortality
Observation in Research
Creatinine

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