Kidney dysfunction in the low-birth weight murine adult: implications of oxidative stress

American Journal of Physiology. Renal Physiology
Wasan AbdulmahdiBrian B Ratliff

Abstract

Maternal undernutrition (MUN) during pregnancy leads to low-birth weight (LBW) neonates that have a reduced kidney nephron endowment and higher morbidity as adults. Using a severe combined caloric and protein-restricted mouse model of MUN to generate LBW mice, we examined the progression of renal insufficiency in LBW adults. Through 6 mo of age, LBW males experienced greater albuminuria (ELISA analysis), a more rapid onset of glomerular hypertrophy, and a worse survival rate than LBW females. In contrast, both sexes experienced a comparable progressive decline in renal vascular density (immunofluorescence analysis), renal blood flow (Laser-Doppler flowmetry analysis), glomerular filtration rate (FITC-sinistrin clearance analysis), and a progressive increase in systemic blood pressure (measured via tail-cuff method). Isolated aortas from both LBW sexes demonstrated reduced vasodilation in response to ACh, indicative of reduced nitric oxide bioavailability and endothelial dysfunction. ELISA and immunofluorescence analysis revealed a significant increase of circulating reactive oxygen species and NADPH oxidase type 4 (NOX4) expression in both LBW sexes, although these increases were more pronounced in males. Although more effectiv...Continue Reading

References

Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J S BeckmanB A Freeman
Oct 1, 1988·American Journal of Hypertension·B M BrennerS Anderson
Aug 4, 1998·General Pharmacology·M P MurphyS W Martin
Dec 29, 2000·Seminars in Thrombosis and Hemostasis·A M SchmidtD M Stern
Jan 3, 2001·Kidney International·W J WelchC S Wilcox
Jan 3, 2001·Kidney International·V M VehaskariJ Manning
Mar 7, 2001·Hypertension·A P ZouA W Cowley
Oct 11, 2001·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·F SekiguchiS Sunano
Apr 6, 2002·American Journal of Physiology. Renal Physiology·Pablo A Ortiz, Jeffrey L Garvin
Apr 22, 2003·Seminars in Nephrology·Thomas H Hostetter
May 20, 2003·Kidney International·Michael HughsonJohn F Bertram
Mar 1, 1962·Journal of Applied Physiology·E R WEIBEL, D M GOMEZ
Mar 26, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Melpomeni PeppaHelen Vlassara
Oct 12, 2004·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jian-Mei Li, Ajay M Shah
Jan 25, 2005·Lancet·A Meguid El Nahas, Aminu K Bello
Jun 18, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Lori L WoodsRuth Rasch
Sep 15, 2005·American Journal of Physiology. Renal Physiology·Taishan HuKumar Sharma
Jan 24, 2006·Journal of Smooth Muscle Research = Nihon Heikatsukin Gakkai Kikanshi·Ednir O VizioliAgnaldo B Chies
Sep 19, 2006·The International Journal of Biochemistry & Cell Biology·Marian ValkoJoshua Telser
Jan 24, 2007·Experimental and Molecular Pathology·Steve R Pieczenik, John Neustadt
Apr 7, 2007·Pediatric Research·Wayne S CutfieldIan M Morison
Aug 10, 2007·Journal of the American Society of Nephrology : JASN·Anja Sachse, Gunter Wolf
Aug 21, 2007·Current Drug Targets·Lori L Woods
Sep 4, 2007·Trends in Endocrinology and Metabolism : TEM·Michelle A CareyDarryl C Zeldin
Dec 7, 2007·Journal of the American Society of Nephrology : JASN·Bjørn Egil VikseBjarne M Iversen
Feb 22, 2008·Hypertension·Michiel P de BoerErik H Serné
Feb 29, 2008·Journal of the American Society of Nephrology : JASN·Stella TranShao-Ling Zhang
May 15, 2008·Journal of Paediatrics and Child Health·Michiel F SchreuderJoanna A E Van Wijk
Aug 13, 2008·Hypertension·Giacomo D SimonettiMarkus G Mohaupt
Sep 30, 2008·Antioxidants & Redox Signaling·Ravi NistalaJames R Sowers
Nov 21, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Jeffrey B HodginVivette D D'Agati
Jan 30, 2009·Journal of Anatomy·Simon C Langley-Evans
Apr 3, 2009·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sarah L WhiteRachel R Huxley
May 23, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Daniel Schock-KuschNorbert Gretz
Mar 5, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Robert A AugustyniakNoreen F Rossi
Nov 4, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Pauline Abou JaoudéPierre Cochat

❮ Previous
Next ❯

Citations

Sep 12, 2019·International Journal of Environmental Research and Public Health·Suhee Kim, Ju-Yeon Uhm
Oct 15, 2019·American Journal of Physiology. Renal Physiology·Luis Enrique García-OrtuñoNorma A Bobadilla
May 13, 2020·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Takeshi KandaHiroshi Itoh

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Software Mentioned

GraphPad
SPOT
NIS Elements AR
ImageJ
GraphPad Prism
NIBPM

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.