Kidney Function and Cardiovascular Events in Postmenopausal Women: The Impact of Race and Ethnicity in the Women's Health Initiative

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Cristina M ArceWomen’s Health Initiative Investigators

Abstract

Kidney disease disproportionately affects minority populations, including African Americans and Hispanics; therefore, understanding the relationship of kidney function to cardiovascular (CV) outcomes within different racial/ethnic groups is of considerable interest. We investigated the relationship between kidney function and CV events and assessed effect modification by race/ethnicity in the Women's Health Initiative. Prospective cohort study. Baseline serum creatinine concentrations (assay traceable to isotope-dilution mass spectrometry standard) of 19,411 postmenopausal women aged 50 to 79 years who self-identified as either non-Hispanic white (n=8,921), African American (n=7,436), or Hispanic (n=3,054) were used to calculate estimated glomerular filtration rates (eGFRs). Categories of eGFR (exposure); race/ethnicity (effect modifier). The primary outcome was the composite of 3 physician-adjudicated CV events: myocardial infarction, stroke, or CV-related death. We evaluated the multivariable-adjusted associations between categories of eGFR and CV events using proportional hazards regression and formally tested for effect modification by race/ethnicity. During a mean follow-up of 7.6 years, 1,424 CV events (653 myocardial inf...Continue Reading

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Citations

Jan 24, 2016·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Holly KramerKunihiro Matsushita
Oct 3, 2019·Pediatric Research·Allison DartNavdeep Tangri

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