Mar 11, 2015

Kidney function and cerebral small vessel disease in the general population

International Journal of Stroke : Official Journal of the International Stroke Society
Saloua AkoudadMeike W Vernooij


Anatomic and hemodynamic similarities between renal and cerebral vessels suggest a tight link between kidney disease and brain disease. Although several distinct markers are used to identify subclinical kidney and brain disease, a comprehensive assessment of how these markers link damage at both end organs is lacking. To investigate whether measures of kidney function were associated with cerebral small vessel disease on MRI. In 2526 participants of the population-based Rotterdam Study, we measured urinary albumin-to-creatinine ratio, and estimated glomerular filtration rate based on serum creatinine and cystatin C. All participants underwent brain magnetic resonance imaging. We assessed presence of cerebral small vessel disease by calculating white matter lesion volumes and rating the presence of lacunes and cerebral microbleeds. We used multivariable linear and logistic regression to investigate the association between kidney function and cerebral small vessel disease. Worse kidney function was consistently associated with a larger white matter lesion volume (mean difference per standard deviation increase in albumin-to-creatinine ratio: 0.09, 95% confidence interval 0.05; 0.12; per standard deviation decrease in creatinine-b...Continue Reading

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Mentioned in this Paper

Biological Markers
Brain Diseases
Magnetic Resonance Imaging
Cerebrovascular System

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