PMID: 4091028Nov 1, 1985

Kidney function in a selected lithium population. A prospective, controlled, lithium-withdrawal study

Acta Psychiatrica Scandinavica
H Bendz


Forty-six lithium (Li) patients who had been on Li for about 1-11 years were studied while on Li and after about 3 months (7 weeks-26 months) off Li. Kidney function was compared between patients on Li and the same patients off Li, and, in 32 matched pairs, between patients on and off Li and psychiatric controls. Urine osmolality (U-osmol) was significantly lower, urine volume higher in patients on Li than in controls. Measures of both glomerular and tubular function improved when Li-patients discontinued medication. U-osmol remained somewhat lower than in controls and was negatively correlated with time-on-Li. Although serum creatinine was somewhat higher in Li-patients off Li than in controls, clearance values were not different between the two groups. Long-term lithium treatment causes a permanent reduction of tubular function. Time-on-Li is a risk factor. In this population the reduction was clinically insignificant. In addition, Li treatment causes a reversible reduction of both tubular and glomerular function. The results can probably be generalized to other outpatient Li populations with the same time-on-Li and with U-osmol below 800 mOsm/kg during ongoing treatment.


Nov 1, 1979·Acta Psychiatrica Scandinavica·P VestergaardM Schou
Sep 1, 1977·Kidney International·J HestbechS Olsen
Nov 1, 1983·Acta Psychiatrica Scandinavica·H Bendz
Nov 1, 1983·Acta Psychiatrica Scandinavica·H BendzM Aurell
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·G Granerus, M Aurell
Dec 1, 1981·Drugs·H E Hansen
Jan 1, 1982·Journal of Chronic Diseases·R G WalkerP Kincaid-Smith
Apr 1, 1981·Acta Psychiatrica Scandinavica·P Vestergaard, A Amdisen
Jul 1, 1980·Pharmakopsychiatrie, Neuro-Psychopharmakologie·J AlbrechtBruno Müller-Oerlinghausen


Jun 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·M WernerR Nayar
Jan 1, 1988·Journal of Psychiatric Research·M Schou
Jun 22, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·H BendzJ Lanke
Nov 1, 1989·Psychological Medicine·D G Waller, J G Edwards
Jan 17, 2007·Journal of Clinical Psychopharmacology·Richard J Silvia, Andrew L Spitznas
Jul 1, 1990·Kidney International·P GrossH Sauer
Jan 24, 2012·Lancet·Rebecca F McKnightJohn R Geddes
Feb 2, 2010·General Hospital Psychiatry·Ching-En Lin, Wei-Chung Mao
May 23, 2006·Seminars in Nephrology·Apurv Khanna
Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Soham RejKenneth Shulman
Dec 19, 2003·European Journal of Clinical Nutrition·F Manz, A Wentz
Apr 11, 2019·Irish Journal of Psychological Medicine·J C KinahanB D Kelly
Mar 10, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·A F Guirguis, H C Taylor
May 10, 2017·International Journal of Bipolar Disorders·Leonardo TondoRoss J Baldessarini
Jul 10, 2014·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Soham RejKarl Looper

Related Concepts

Urgent Care
Diagnosis, Psychiatric
Kidney Diseases
Kidney Function Tests
Kidney Glomerulus
Renal Tubule Structure

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.

Related Papers

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
H BendzM Aurell
European Psychiatry : the Journal of the Association of European Psychiatrists
M CuestaV Peralta
© 2021 Meta ULC. All rights reserved