PMID: 4091028Nov 1, 1985

Kidney function in a selected lithium population. A prospective, controlled, lithium-withdrawal study

Acta Psychiatrica Scandinavica
H Bendz

Abstract

Forty-six lithium (Li) patients who had been on Li for about 1-11 years were studied while on Li and after about 3 months (7 weeks-26 months) off Li. Kidney function was compared between patients on Li and the same patients off Li, and, in 32 matched pairs, between patients on and off Li and psychiatric controls. Urine osmolality (U-osmol) was significantly lower, urine volume higher in patients on Li than in controls. Measures of both glomerular and tubular function improved when Li-patients discontinued medication. U-osmol remained somewhat lower than in controls and was negatively correlated with time-on-Li. Although serum creatinine was somewhat higher in Li-patients off Li than in controls, clearance values were not different between the two groups. Long-term lithium treatment causes a permanent reduction of tubular function. Time-on-Li is a risk factor. In this population the reduction was clinically insignificant. In addition, Li treatment causes a reversible reduction of both tubular and glomerular function. The results can probably be generalized to other outpatient Li populations with the same time-on-Li and with U-osmol below 800 mOsm/kg during ongoing treatment.

References

Nov 1, 1979·Acta Psychiatrica Scandinavica·P VestergaardM Schou
Sep 1, 1977·Kidney International·J HestbechS Olsen
Nov 1, 1983·Acta Psychiatrica Scandinavica·H Bendz
Nov 1, 1983·Acta Psychiatrica Scandinavica·H BendzM Aurell
Oct 1, 1981·Scandinavian Journal of Clinical and Laboratory Investigation·G Granerus, M Aurell
Dec 1, 1981·Drugs·H E Hansen
Jan 1, 1982·Journal of Chronic Diseases·R G WalkerP Kincaid-Smith
Apr 1, 1981·Acta Psychiatrica Scandinavica·P Vestergaard, A Amdisen
Jul 1, 1980·Pharmakopsychiatrie, Neuro-Psychopharmakologie·J AlbrechtBruno Müller-Oerlinghausen

Citations

Jun 15, 1995·Clinica Chimica Acta; International Journal of Clinical Chemistry·M WernerR Nayar
Jan 1, 1988·Journal of Psychiatric Research·M Schou
Jun 22, 2001·European Psychiatry : the Journal of the Association of European Psychiatrists·H BendzJ Lanke
Nov 1, 1989·Psychological Medicine·D G Waller, J G Edwards
Jan 17, 2007·Journal of Clinical Psychopharmacology·Richard J Silvia, Andrew L Spitznas
Jul 1, 1990·Kidney International·P GrossH Sauer
Jan 24, 2012·Lancet·Rebecca F McKnightJohn R Geddes
Feb 2, 2010·General Hospital Psychiatry·Ching-En Lin, Wei-Chung Mao
May 23, 2006·Seminars in Nephrology·Apurv Khanna
Apr 3, 2012·Journal of Geriatric Psychiatry and Neurology·Soham RejKenneth Shulman
Dec 19, 2003·European Journal of Clinical Nutrition·F Manz, A Wentz
Apr 11, 2019·Irish Journal of Psychological Medicine·J C KinahanB D Kelly
Mar 10, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·A F Guirguis, H C Taylor
May 10, 2017·International Journal of Bipolar Disorders·Leonardo TondoRoss J Baldessarini
Jul 10, 2014·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·Soham RejKarl Looper

Related Concepts

Urgent Care
Diagnosis, Psychiatric
Krebiozen
Kidney Diseases
Kidney Function Tests
Kidney Glomerulus
Renal Tubule Structure
Lithium
Osmolality
Urine

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