Abstract
Renal failure as a consequence of manifest lead intoxication (nephropathia saturnina) has almost completely disappeared in the FRG. However, there has been rising concern that increased lead burden, primarily as a result of environmental pollution, may adversely affect blood pressure and renal function even in the absence of extrarenal signs of lead intoxication. Such concern is based on epidemiological studies which demonstrated a relation between blood lead level and blood pressure and on experimental studies which showed that lead activates several pressor mechanisms. Furthermore, increased body lead burden is found in a substantial proportion of patients with renal failure, particularly when concomitant gout is present. Unfortunately, none of the above findings constitute irrefutable evidence and further studies are clearly necessary.
References
Mar 4, 1978·British Medical Journal·O BertelJ Ott
Nov 1, 1978·Toxicology and Applied Pharmacology·D R MouwN Fleischer
May 1, 1975·Neuropharmacology·E K Silbergeld, A M Goldberg
Jan 1, 1986·Nephron·D BehringerE Ritz
Jan 1, 1986·Nephron·N Colleoni, G D'Amico
Jan 19, 1985·British Medical Journal·G OrssaudB Festy
Feb 1, 1985·Scandinavian Journal of Work, Environment & Health·H Kirkby, F Gyntelberg
Feb 1, 1985·American Journal of Epidemiology·J L PirkleW R Harlan
Sep 1, 1985·American Journal of Epidemiology·D KromhoutR L Zielhuis
Jul 1, 1973·Kidney International·B T Emmerson
Nov 1, 1965·Klinische Wochenschrift·H Sarre, D P Mertz
Jul 7, 1983·The New England Journal of Medicine·V BatumanR P Wedeen
Sep 1, 1984·Kidney International·P W CraswellB W Thomas
Feb 26, 1981·The New England Journal of Medicine·V BatumanR P Wedeen
Aug 1, 1982·The Science of the Total Environment·G A Drasch
May 15, 1980·The New England Journal of Medicine·J F RosenK R Mahaffey
Feb 1, 1965·Australasian Annals of Medicine·J D TANGED A BREMNER