Kidney Function Surveillance in the National Spina Bifida Patient Registry: A Retrospective Cohort Study.

The Journal of Urology
David I ChuTamara Isakova

Abstract

Chronic kidney disease affects 25% to 50% of patients with spina bifida. Guidelines recommend kidney function surveillance in these patients but practice patterns are unknown. Variations in kidney function surveillance were assessed in patients with spina bifida based on the hypothesis that the treating clinic and spina bifida type would be associated with kidney function surveillance. A retrospective cohort study was conducted of U.S. patients in the National Spina Bifida Patient Registry from 2013 to 2018. Followup was anchored at the 2013 visit. Participants with either an outcome event within 2 years of followup or more than 2 years of followup without an outcome event were included. Primary outcome was kidney function surveillance, defined as at least 1 renal ultrasound and serum creatinine within 2 years of followup. Primary exposures were clinic and spina bifida type, which were analyzed with covariates including sociodemographic and clinical characteristics in logistic regression models for their association with the outcome. Sensitivity analyses were performed using different kidney function surveillance definitions. Of 8,351 patients 5,445 were included with a median followup of 3.0 years. Across 23 treating clinics k...Continue Reading

Citations

Dec 1, 2020·Journal of Pediatric Rehabilitation Medicine·David B JosephHadley Wood

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