Kidney injury in infants and children with iron-deficiency anemia before and after iron treatment

Hematology
Rasha H HassanAshraf E Fouda

Abstract

Our study aimed to investigate the effects of iron-deficiency anemia (IDA) on renal tubular functions before and after iron treatment for infants and children with IDA. We measured urinary levels of two kidney injury markers: neutrophil gelatinase-associated lipocalin (NGAL) and liver-type fatty acid-binding protein (L-FABP). Thirty-six infants and children with IDA and 20 matched healthy controls were included. We assessed different laboratory parameters, estimated glomerular filtration rate, urinary levels of NGAL, and L-FABP. Urinary kidney injury markers were measured in IDA patients before and after 3 months of oral iron therapy. IDA patients had significantly higher urinary NGAL and L-FABP levels compared to their healthy controls. After 3 months of oral iron treatment, there was a significant improvement (decrease) in urinary NGAL and L-FABP in infants and children with IDA. Urinary markers returned to normal levels (healthy control levels) in children with IDA, but not for infants with IDA compared to their healthy controls. Subclinical kidney injury was found in infants and children with IDA. This injury was completely reversible in older children with IDA and partially reversible in infants with IDA after iron therapy...Continue Reading

References

Feb 13, 2001·The Journal of Nutrition·S Grantham-McGregor, C Ani
Mar 20, 2003·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Figen OzçayUmit Saatçi
Dec 8, 2004·Journal of the American Society of Nephrology : JASN·Jaya MishraPrasad Devarajan
Jul 25, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Atsuko Kamijo-IkemoriKenjiro Kimura
Dec 13, 2006·Seminars in Fetal & Neonatal Medicine·Raghavendra Rao, Michael K Georgieff
Aug 19, 2007·Lancet·Michael B Zimmermann, Richard F Hurrell
Sep 18, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Russel HirschPrasad Devarajan
May 24, 2008·Public Health Nutrition·Erin McLeanBruno de Benoist
Jan 30, 2009·Clinical Journal of the American Society of Nephrology : CJASN·Davide BolignanoMichele Buemi
Apr 1, 2010·Kidney International·Blaithin A McMahon, Patrick Thomas Murray
Oct 11, 2012·British Journal of Anaesthesia·J MårtenssonM Bell
Jan 19, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Edward R SmithStephen G Holt
Dec 24, 2014·Nutrients·Samuel P ScottLaura E Murray-Kolb
Feb 1, 2015·Indian Journal of Pediatrics·Girish Subramaniam, Meenakshi Girish
May 20, 2015·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mohamed S El-ShimiSara M Shoukry
Dec 25, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ali Güneşİlyas Yolbaş

❮ Previous
Next ❯

Citations

Sep 27, 2019·Nature Reviews. Nephrology·Rachel P L van SwelmDorine W Swinkels

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Ali Güneşİlyas Yolbaş
Clinical Chemistry and Laboratory Medicine : CCLM
Leon HolzscheiterWalter Hofmann
© 2022 Meta ULC. All rights reserved