Kidney injury is independent of endothelial HIF-1α

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Joanna KaluckaAlexander Weidemann

Abstract

Hypoxia-inducible transcription factors (HIFs) control cellular adaptation to low oxygen. In the kidney, activation of HIF is beneficial during injury; however, the specific contribution of HIF-1α in renal endothelial cells (EC) remains elusive. Since EC display tissue-specific heterogeneity, we investigated how HIF-1α affects key functions of glomerular EC in vitro and its contribution to renal development and pathophysiological adaptation to acute or chronic renal injury in vivo. Loss of HIF-1α in glomerular EC induces hypoxic cell death and reduces hypoxic adhesion of macrophages in vitro. In vivo, HIF-1α expression in EC in mouse kidneys is detectable but limited. Accordingly, EC-specific ablation of HIF-1α does not lead to developmental or phenotypical abnormalities in the kidney. Renal function and expression of adhesion molecules during acute ischemic kidney injury is independent of HIF-1α in EC. Likewise, inflammation and development of fibrosis after unilateral ureteric obstruction is not influenced by endothelial HIF-1α. Taken together, although HIF-1α exerts effects on glomerular EC in vitro, endothelial HIF-1α does not influence renal development and pathophysiological adaptation to kidney injury in vivo. This impli...Continue Reading

References

Feb 13, 2001·Developmental Biology·Y Y KisanukiM Yanagisawa
Mar 23, 2001·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·A S Woolf, H T Yuan
Nov 2, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·D M StrokaD Candinas
Feb 19, 2002·Kidney International·Michael S GoligorskyEisei Noiri
Apr 18, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Michael D BentleyJ Carlos Romero
Jun 29, 2002·Journal of the American Society of Nephrology : JASN·Christian RosenbergerKai-Uwe Eckardt
Oct 11, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Amanda W WyattGiovanni E Mann
Dec 17, 2002·Molecular and Cellular Biology·Nobuhito GodaRandall S Johnson
Dec 20, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael S WiesenerKai-Uwe Eckardt
Jul 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jan Steffen JürgensenKai-Uwe Eckardt
Dec 24, 2005·Kidney International·W M BernhardtK-U Eckardt
Feb 9, 2007·Journal of the American Society of Nephrology : JASN·Christoph DanielChristian Hugo
Feb 9, 2008·Cell Death and Differentiation·A Weidemann, R S Johnson
Nov 28, 2008·American Journal of Physiology. Renal Physiology·Takahiro NakayamaTakahiko Nakagawa
Jan 10, 2009·Nature Protocols·Daniel RittirschPeter A Ward
Dec 19, 2009·The Journal of Biological Chemistry·Jana SamarinMargarete Goppelt-Struebe
Sep 30, 2010·Nature Reviews. Nephrology·Imari Mimura, Masaomi Nangaku
Jan 24, 2012·Cancer Cell·Cristina Branco-PriceRandall S Johnson
Mar 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Hong WeiGregg L Semenza
Jun 16, 2012·Proceedings of the National Academy of Sciences of the United States of America·Kakali SarkarGregg L Semenza
Sep 5, 2012·The American Journal of Pathology·Gunnar SchleyCarsten Willam
Oct 11, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yan HuangFrank J Giordano
Jun 26, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Xinguo JiangMark R Nicolls
Oct 23, 2013·Cell Communication and Signaling : CCS·Alexander WeidemannMargarete Goppelt-Struebe
May 3, 2014·The Journal of Clinical Investigation·Pinelopi P KapitsinouVolker H Haase

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Citations

Feb 10, 2016·Clinical and Experimental Nephrology·Tetsuhiro Tanaka
Jan 17, 2017·Laboratory Investigation; a Journal of Technical Methods and Pathology·Qi LiJoseph A Madri
Feb 14, 2017·Annual Review of Physiology·Sarah C Huen, Lloyd G Cantley
May 5, 2017·International Journal of Molecular Sciences·Jing LiuZheng Dong
Jul 19, 2019·Cell Biochemistry and Function·Jéssica Freitas Araújo EncinasGlaucia Luciano da Veiga
Aug 28, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Zuo-Lin LiBi-Cheng Liu
Jan 31, 2020·Journal of the American Society of Nephrology : JASN·Ganeshkumar RajendranPinelopi P Kapitsinou
Nov 8, 2020·International Journal of Molecular Sciences·Yujiro Kida
Mar 27, 2021·Nature Reviews. Nephrology·Sébastien J DumasPeter Carmeliet

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