Kidney injury molecule-1: potential biomarker of acute kidney injury and disease severity in patients with COVID-19.

Journal of Nephrology
Manuel J VogelJulian Hupf

Abstract

The aim of the current study was to evaluate whether tubular markers kidney injury molecule-1 (KIM-1) and N-acetyl-ß-glucosaminidase (NAG) are related to acute kidney injury (AKI) and severe disease in patients with COVID-19. In this prospective observational clinical trial we examined a cohort of 80 patients with proof of acute respiratory infection and divided them into a COVID-19 cohort (n = 54) and a control cohort (n = 26). KIM-1 and NAG were measured from urine samples collected in the emergency department. We assessed the development of AKI, admission to the intensive care unit (ICU) and intrahospital death as clinical endpoints. Urinary KIM-1 and NAG were not significantly different between patients with SARS-CoV-2 and those with other respiratory infections (each p = n.s.). Eight patients from the COVID-19 cohort and five of the non-COVID-19-patients suffered from acute kidney injury during their stay. Nine COVID-19 patients and two non-COVID-19 patients were admitted to the ICU. KIM-1 was significantly elevated in COVID-19 patients with, compared to those without AKI (p = 0.005), as opposed to NAG and creatinine (each p = n.s.). Furthermore, KIM-1 was significantly elevated in the patients with COVID-19 that had to be...Continue Reading

References

Dec 1, 1996·Journal of Clinical Epidemiology·P PeduzziA R Feinstein
Feb 4, 2006·BMJ : British Medical Journal·Jayne Haynes, Richard Haynes
Feb 3, 2007·Journal of the American Society of Nephrology : JASN·Orfeas LiangosBertrand L Jaber
May 6, 2009·Annals of Internal Medicine·Andrew S LeveyUNKNOWN CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
Oct 30, 2015·BMJ : British Medical Journal·Patrick M BossuytUNKNOWN STARD Group
Dec 25, 2016·European Journal of Internal Medicine·Michele AndreucciAshour Michael
May 10, 2017·Frontiers in Immunology·Hua SuChun Zhang
Sep 12, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Rafael N MorescoYãnaí S Bollick
Nov 30, 2019·Lancet·Claudio RoncoJohn A Kellum
Apr 1, 2020·The New England Journal of Medicine·Muthiah VaduganathanScott D Solomon
May 6, 2020·Intensive Care Medicine·Julie HelmsUNKNOWN CRICS TRIGGERSEP Group (Clinical Research in Intensive Care and Sepsis Trial Group for Global Evaluation and Research in Sep
May 18, 2020·Kidney International·Jamie S HirschUNKNOWN Northwell Nephrology COVID-19 Research Consortium
May 18, 2020·The Lancet. Respiratory Medicine·Claudio RoncoFaeq Husain-Syed
Jun 14, 2020·Intensive Care Medicine·Paul GabarreLara Zafrani
Jul 14, 2020·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Panupong HansrivijitNasrollah Ghahramani
Jan 28, 2021·Nephrology·Cigdem YildirimMurat Dizbay
Mar 5, 2021·Clinical Journal of the American Society of Nephrology : CJASN·Alexandre KarrasNicolas Pallet
Apr 6, 2021·Clinical Kidney Journal·Muner M B Mohamed, Juan Carlos Q Velez

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