Abstract
Kidney involvement in Waldenström macroglobulinemia is less well described compared with kidney manifestations in multiple myeloma. Of the 1363 patients seen with Waldenström macroglobulinemia and other IgM-secreting B cell lymphoproliferative disorders seen at the Mayo Clinic between 1996 and 2015, 57 kidney biopsies were retrospectively studied. The biopsy findings were correlated with clinical, kidney, and hematologic characteristics. Criteria for inclusion were evidence of a monoclonal IgM protein and availability of a kidney and a bone marrow biopsy for review. Glomerular and tubulointerstitial pathologies were categorized according to whether they were related to the monoclonal IgM. Of the 57 patients identified, monoclonal gammopathy-related kidney lesions were identified in 82% (47 of 57 biopsies), whereas nonmonoclonal gammopathy-related kidney lesions were seen in 18% (ten of 57). Monoclonal gammopathy-related kidney lesions included monoclonal Ig-related amyloidosis (n=19; 33%), nonamyloid glomerulopathy (n=20, 35%), and tubulointerstitial nephropathies (n=8; 14%). The most common monoclonal gammopathy-related kidney lesion was monoclonal Ig-related amyloidosis (n=19; 33%) followed by cryoglobulinemic GN (n=13; 28%)....Continue Reading
References
Jul 16, 1970·The New England Journal of Medicine·L Morel-MarogerG Richet
Apr 30, 2003·Seminars in Oncology·Roger G OwenMeletios A Dimopoulos
Jul 18, 2008·Clinical Journal of the American Society of Nephrology : CJASN·Vincent AudardPierre Ronco
Jul 24, 2010·Rheumatology International·Tomohiro KogaKatsumi Eguchi
Aug 13, 2010·Mayo Clinic Proceedings·Stephen M AnsellMorie A Gertz
Sep 16, 2010·American Journal of Hematology·Steven R SchusterJoseph Mikhael
Oct 11, 2012·Blood·Nelson LeungUNKNOWN International Kidney and Monoclonal Gammopathy Research Group
Oct 24, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Giovanni PalladiniGiampaolo Merlini
Nov 16, 2012·British Journal of Haematology·Roger G OwenUNKNOWN VIth International Workshop on Waldenström macroglobulinaemia
Dec 13, 2012·Hematology·Irene M Ghobrial
May 20, 2015·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Sophie ChauvetGuy Touchard
Jul 21, 2016·Leukemia·M VignonJ P Fermand
Jul 30, 2016·British Journal of Haematology·Josephine M VosJorge J Castillo
Oct 21, 2016·American Journal of Hematology·Taxiarchis V KourelisNelson Leung
Jan 11, 2017·Blood·Sophie ChauvetFrank Bridoux
Feb 9, 2017·Nephrology·Usman MahmoodRoss Francis
Citations
Nov 30, 2018·Journal of Clinical Laboratory Analysis·Hong ZouHui-Fang Huang
Feb 26, 2019·Clinical Medicine Insights. Case Reports·Muddasir Ashraf, Prerna Rastogi
Jan 22, 2020·Leukemia & Lymphoma·Iuliana Vaxman, Morie Gertz
Nov 1, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nupur N UppalKenar D Jhaveri
Sep 19, 2019·Blood·Meletios A Dimopoulos, Efstathios Kastritis
Sep 11, 2020·Case Reports in Nephrology·Akshee BatraBijin Thajudeen
Oct 20, 2018·Journal of Nephrology·Serena Yen Shan TanMegan Leigh Troxell
Mar 30, 2020·Medicine·Qin ChenWei Wang
Jul 30, 2020·Journal of Nephrology·Dandan LiangZhihong Liu
Jan 26, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Frank BridouxNelson Leung
Jan 14, 2021·Kidney International·Frank BridouxUNKNOWN International Kidney and Monoclonal Gammopathy Research Group
Jan 14, 2020·Clinics and Practice·Thomas KnoopHåkon Reikvam
Mar 18, 2021·Nephrology·Chi Yuen CheungSydney C W Tang
Apr 1, 2021·Nature Reviews. Nephrology·Frank BridouxNelson Leung
Apr 13, 2021·Indian Journal of Nephrology·Kiran P MalhotraTripti Verma
May 1, 2021·Diagnostics·Antoine MorelVincent Audard
May 20, 2021·The New England Journal of Medicine·Nelson LeungSamih H Nasr
Jun 4, 2021·Journal of Investigative Medicine High Impact Case Reports·Hassaan JafriToni Pacioles
Sep 9, 2021·Journal of Nephrology·Charles RonsinSimon Ville