Kidney manifestations of mild, moderate and severe coronavirus disease 2019: a retrospective cohort study

Clinical Kidney Journal
Daqing HongLi Wang

Abstract

Coronavirus disease 2019 (COVID-19) is a pandemic that has affected more than 3 million patients globally. Previous data from Wuhan city showed that acute kidney injury (AKI), proteinuria and hematuria occurred frequently in patients with severe COVID-19. However, the prevalence of kidney injury in milder cases remains unclear. This retrospective study included two major consecutive cohorts of COVID-19 patients in Sichuan Province. Baseline characteristics, laboratory data including renal function, proteinuria and dipstick hematuria, and other laboratory parameters were collected. A subgroup of patients was followed up for 2-4 weeks to evaluate the short-term outcome of renal impairment. Overall, 168 COVID-19-positive patients were included in the study. The majority of patients (79.7%) were diagnosed with mild or moderate disease. Half of patients presented with fever; however, in The Tibetan cohort, fever only occurred in 13.4% of patients. On hospital admission, proteinuria and dipstick hematuria were noted in 18.4% and 17.4% of patients, respectively, while AKI only occurred in one patient. Further analysis showed that severe or critical COVID-19 was associated with higher risk of proteinuria [relative risk (RR) 7.37, 95% c...Continue Reading

References

Jan 28, 2005·Kidney International·Kwok Hong ChuKar Neng Lai
Jan 25, 2020·The New England Journal of Medicine·Na ZhuUNKNOWN China Novel Coronavirus Investigating and Research Team
Feb 23, 2020·Science·Daniel WrappJason S McLellan
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Mar 25, 2020·Kidney International·Saraladevi NaickerVivekanand Jha
Apr 6, 2020·Kidney International·Yichun ChengGang Xu

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Citations

Jul 24, 2020·Clinical Kidney Journal·Sol CarriazoAlberto Ortiz
Sep 16, 2020·Medicina·Allison B ReissEric R Goldberg
Mar 14, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Felipe Ten-CatenHelder I Nakaya
May 25, 2021·Journal of Research in Health Sciences·Naser NasiriAli Sharifi

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