Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice

Journal of the American Heart Association
Samyuktha Muralidharan PillaiFrançois Verrey

Abstract

Uninephrectomy (UNX) is performed for various reasons, including kidney cancer or donation. Kidneys being the main site of l-arginine production in the body, we tested whether UNX mediated kidney mass reduction impacts l-arginine metabolism and thereby nitric oxide production and blood pressure regulation in mice. In a first series of experiments, we observed a significant increase in arterial blood pressure 8 days post-UNX in female and not in male mice. Further experimental series were performed in female mice, and the blood pressure increase was confirmed by telemetry. l-citrulline, that is used in the kidney to produce l-arginine, was elevated post-UNX as was also asymmetric dimethylarginine, an inhibitor of nitric oxide synthase that competes with l-arginine and is a marker for renal failure. Interestingly, the UNX-induced blood pressure increase was prevented by supplementation of the diet with 5% of the l-arginine precursor, l-citrulline. Because l-arginine is metabolized in the kidney and other peripheral tissues by arginase-2, we tested whether the lack of this metabolic pathway also compensates for decreased l-arginine production in the kidney and/or for local nitric oxide synthase inhibition and consecutive blood pre...Continue Reading

References

Dec 1, 1977·Endocrinology·D SchlondorffS Korth-Schutz
Apr 1, 1977·The Journal of Pediatrics·S E SnydermanS V Phansalkar
Feb 1, 1995·Kidney International·O LevillainP P de Deyn
Dec 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·R J MacAllisterE Ritz
Apr 1, 2003·The Journal of Physiology·Bruce N Van VlietJean-Pierre Montani
Jan 30, 2004·The American Journal of Clinical Nutrition·Marcel C G van de PollCornelis H C Dejong
Feb 11, 2004·Pflügers Archiv : European journal of physiology·François VerreyYoshikatsu Kanai
Apr 21, 2005·The Journal of Clinical Investigation·Steven D CrowleyThomas M Coffman
Sep 22, 2005·American Journal of Physiology. Renal Physiology·Elisa RomeoFrançois Verrey
Aug 2, 2006·Annals of Internal Medicine·Neil BoudvilleUNKNOWN Donor Nephrectomy Outcomes Research (DONOR) Network
Aug 26, 2006·Nature Clinical Practice. Nephrology·Chris Baylis
Nov 9, 2006·Proceedings of the National Academy of Sciences of the United States of America·Steven D CrowleyThomas M Coffman
Jan 12, 2007·Cardiovascular Drug Reviews·Maritza J RomeroR William Caldwell
May 8, 2007·Pharmacology & Therapeutics·Stefanie M Bode-BögerLouis J Ignarro
Jul 25, 2007·Clinical and Experimental Pharmacology & Physiology·William DuranteRobert A Johnson
Dec 15, 2007·Metabolism: Clinical and Experimental·Olivier LevillainPatrick Vinay
Mar 20, 2009·American Journal of Physiology. Renal Physiology·Mukut SharmaElias A Lianos
Sep 19, 2009·Methods in Molecular Biology·Daniel A Huetteman, Heather Bogie
Aug 20, 2010·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Luc CynoberJean-Pascal De Bandt
Nov 15, 2011·BMJ Open·Gilbert T ThielDimitrios Tsinalis
Jul 17, 2012·Journal of the American Society of Nephrology : JASN·Thomas F Mueller, Valerie A Luyckx
Oct 17, 2012·Hypertension·Isabel Rodríguez-GómezFélix Vargas
Oct 8, 2014·Journal of Cellular and Molecular Medicine·Clintoria R WilliamsJennifer L Gooch
Mar 19, 2015·Kidney International·Dominic M SummersJ Andrew Bradley
May 20, 2015·The Journal of Clinical Investigation·Jian-Kang ChenRaymond C Harris
Jan 13, 2016·Hypertension·William E MoodyUNKNOWN CRIB-Donor Study Investigators
Apr 9, 2016·Journal of the American Society of Nephrology : JASN·Svetlana NikolaevaDmitri Firsov
May 29, 2016·Transplantation Proceedings·K W ChenH Y Tiong
Jun 9, 2017·Journal of the American Society of Nephrology : JASN·Fanny LepeytreBethany J Foster

❮ Previous
Next ❯

Citations

May 3, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ji HuangZhihong Yang
Oct 26, 2018·JPEN. Journal of Parenteral and Enteral Nutrition·Mahmoud A MohammadJuan C Marini
Apr 1, 2019·Veterinary World·Olayinka Christianah JayeolaOluwafemi Omoniyi Oguntibeju
Aug 27, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Shao-Bo LiuXi-Jun Wang

❮ Previous
Next ❯

Software Mentioned

GraphPad
GraphPad Prism
Dataquest ART

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.