Kidney morphology and function in the young of rats malnourished and exposed to nitrofen during pregnancy

Journal of Toxicology and Environmental Health
C Chase-DeesingF J Zeman

Abstract

The separate and combined effects of prenatal protein deficiency (6% casein) and prenatal nitrofen (2,4-dichlorophenyl-p-nitrophenyl ether) exposure (12.5 mg/kg on gestational d 7-21) on renal morphology in the 21-d fetal and postnatal rat were examined. Body weights and kidney weights were reduced in prenatally protein-deprived (PPD) pups at birth and on postnatal day (PND) 10. Numbers of mature glomeruli, creatinine clearance, water diuresis, and response of antidiuretic hormone (ADH), but not the concentrating ability, were lower in the PPD neonates. These changes suggest that prenatal protein deficiency delays renal development and possibly results in a decrease in glomerular clearance and in tubular response to a water load and to antidiuretic hormone. Prenatal nitrofen exposure reduced body weight and kidney size on PND 0 and 10. An increased incidence of hydronephrosis was indicated in the nitrofen-exposed fetus. Prenatal nitrofen exposure depressed the ability to excrete excess water, the response to ADH, and urine-concentrating ability. The functional deficits indicate tubular dysfunction, but little or no effect on glomerular function, as indicated by the absence of an effect on creatinine clearance. Postnatal surviva...Continue Reading

References

Dec 1, 1985·Toxicology and Applied Pharmacology·R J KavlockE H Rogers
Oct 1, 1973·The Journal of Nutrition·L H Allen, F J Zeman
Jun 1, 1974·Archives of Environmental Health·R D KimbroughR E Linder
Jun 1, 1971·Toxicology and Applied Pharmacology·A M AmbroseG R Hennigar
Nov 1, 1970·Journal of Agricultural and Food Chemistry·E M Boyd, V Krupa
May 1, 1968·The Journal of Nutrition·S M Hall, F J Zeman
Oct 1, 1967·The Journal of Nutrition·F J Zeman
Jan 1, 1983·Journal of Toxicology and Environmental Health·R J Kavlock, J A Gray
Apr 1, 1983·Journal of Toxicology and Environmental Health·R J Kavlock, L E Gray
Aug 1, 1983·The Journal of Nutrition·M B Grosvenor, F J Zeman
Jan 1, 1982·Biology of the Neonate·R J Kavlock, J A Gray
Sep 1, 1953·The Journal of Nutrition·M M NELSON, H M EVANS
Apr 1, 1955·The American Journal of Physiology·G FALK

❮ Previous
Next ❯

Citations

Apr 1, 1996·Pediatric Surgery International·B QiJ A Tovar
Sep 1, 1996·Journal of Pediatric Surgery·B QiJ A Tovar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.