Kidney NGAL is a novel early marker of acute injury following transplantation

Pediatric Nephrology : Journal of the International Pediatric Nephrology Association
Jaya MishraPrasad Devarajan

Abstract

Acute kidney injury secondary to ischemia-reperfusion in renal allografts often results in delayed graft function. We tested the hypothesis that expression of neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury following transplantation. Sections from paraffin-embedded protocol biopsy specimens obtained at approximately one hour of reperfusion after transplantation of 13 cadaveric (CAD) and 12 living-related (LRD) renal allografts were examined by immunohistochemistry for expression of NGAL. The staining intensity was correlated with cold ischemia time, peak post-operative serum creatinine, and dialysis requirement. There were no differences between the LRD and CAD groups in age, gender or preoperative serum creatinine. Using a scoring system of 0 (no staining) to 3 (most intense staining), NGAL expression was significantly increased in CAD specimens (2.3+/-0.8 versus 0.8+/-0.7 in LRD, p<0.001). There was a strong correlation between NGAL staining intensity and cold ischemia time (R=0.87, p<0.001). Importantly, NGAL staining in these early CAD biopsies was strongly correlated with peak postoperative serum creatinine, which occurred days later (R=0.86, p<0.001). Four patients developed del...Continue Reading

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Citations

Aug 21, 2013·Intensive Care Medicine·Matthieu LegrandMichael Joannidis
Oct 31, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mark M MitsnefesPrasad Devarajan
Mar 31, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Mai T Nguyen, Prasad Devarajan
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