Kidney organogenesis in the zebrafish: insights into vertebrate nephrogenesis and regeneration

Wiley Interdisciplinary Reviews. Developmental Biology
Gary F Gerlach, Rebecca A Wingert

Abstract

Vertebrates form a progressive series of up to three kidney organs during development-the pronephros, mesonephros, and metanephros. Each kidney derives from the intermediate mesoderm and is comprised of conserved excretory units called nephrons. The zebrafish is a powerful model for vertebrate developmental genetics, and recent studies have illustrated that zebrafish and mammals share numerous similarities in nephron composition and physiology. The zebrafish embryo forms an architecturally simple pronephros that has two nephrons, and these eventually become a scaffold onto which a mesonephros of several hundred nephrons is constructed during larval stages. In adult zebrafish, the mesonephros exhibits ongoing nephrogenesis, generating new nephrons from a local pool of renal progenitors during periods of growth or following kidney injury. The characteristics of the zebrafish pronephros and mesonephros make them genetically tractable kidney systems in which to study the functions of renal genes and address outstanding questions about the mechanisms of nephrogenesis. Here, we provide an overview of the formation and composition of these zebrafish kidney organs, and discuss how various zebrafish mutants, gene knockdowns, and transge...Continue Reading

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Citations

Nov 5, 2013·Translational Research : the Journal of Laboratory and Clinical Medicine·Kristen K McCampbell, Rebecca A Wingert
Mar 5, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Richard W Naylor, Alan J Davidson
Jun 13, 2014·Genesis : the Journal of Genetics and Development·Paul T Kroeger, Rebecca A Wingert
Dec 3, 2014·Gene Expression Patterns : GEP·Robert McKeeRebecca A Wingert
Jun 20, 2015·Stem Cells International·Kristen K McCampbellRebecca A Wingert
May 15, 2015·Current Pathobiology Reports·Robert A McKee, Rebecca A Wingert
Jul 9, 2016·Genesis : the Journal of Genetics and Development·Amanda N MarraRebecca A Wingert
Dec 9, 2016·World Journal of Stem Cells·Brooke E Chambers, Rebecca A Wingert
Sep 27, 2014·World Journal of Stem Cells·Elvin E Morales, Rebecca A Wingert
Mar 17, 2016·World Journal of Stem Cells·Bridgette E Drummond, Rebecca A Wingert
Nov 27, 2018·ELife·Joseph M ChambersRebecca A Wingert
Jul 28, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katharina Schütte-NütgenHermann Pavenstädt
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Nov 18, 2016·American Journal of Physiology. Renal Physiology·Simone Kersten, Francisco J Arjona
Dec 24, 2018·Scientific Reports·Elvin E MoralesRebecca A Wingert
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Jun 5, 2019·Development·Brooke E ChambersRebecca A Wingert
Apr 6, 2019·Proceedings of the National Academy of Sciences of the United States of America·Amanda N MarraRebecca A Wingert
Oct 24, 2020·Tissue Barriers·Joseph M Chambers, Rebecca A Wingert
Nov 27, 2020·Journal of Toxicologic Pathology·Izuru Miyawaki

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