Kidney residency of VISTA-positive macrophages accelerates repair from ischemic injury.

Kidney International
Jun-Gyu ParkSeung Seok Han

Abstract

Tissue-resident macrophages have unique tissue-specific functions in maintaining homeostasis and resolving inflammation. However, the repair role and relevant molecules of kidney-resident macrophages after ischemic injury remain unresolved. To this end, mice without kidney-resident R1 macrophages but containing infiltrating monocyte-derived R2 macrophages were generated using differential cellular kinetics following clodronate liposome treatment. When ischemia-reperfusion injury was induced in these mice, late phase repair was reduced. Transcriptomic and flow cytometric analyses identified that V-domain Ig suppressor of T cell activation (VISTA), an inhibitory immune checkpoint molecule, was constitutively expressed in kidney-resident R1 macrophages, but not in other tissue-resident macrophages. Here, VISTA functioned as a scavenger of apoptotic cells and served as a checkpoint to control kidney-infiltrating T cells upon T cell receptor-mediated stimulation. Together these functions improved the repair process after ischemia-reperfusion injury. CD14+ CD33+ mononuclear phagocytes of human kidney also expressed VISTA, which has similar functions to the mouse counterpart. Thus, VISTA is upregulated in kidney macrophages in a tissu...Continue Reading

Citations

Sep 26, 2020·Scientific Reports·Jun-Gyu ParkSeung Seok Han
Jan 27, 2021·Trends in Immunology·Long YuanGordon J Freeman
Mar 4, 2021·NAR Genomics and Bioinformatics·Dustin J SokolowskiMichael D Wilson
Jun 8, 2021·Frontiers in Immunology·Yi WenBi-Cheng Liu
Jun 15, 2021·Frontiers in Medicine·William T Nash, Mark D Okusa

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