PMID: 6987327Mar 1, 1980Paper

Kidney-specific alloantigen system in the rat. Characterization and role in transplantation

The Journal of Experimental Medicine
D N Hart, J W Fabre

Abstract

The alloantibody response of LEW rats immunized with DA kidney homogenate or given vascularized DA kidney grafts was studied using an 125I-anti-Ig binding assay with kidney homogenate as the target tissue. A major component of the sera was found to be directed at a kidney-specific alloantigen. Analysis of LEW X (DA X LEW) F1 backcross rats showed that the locus coding for this antigen was not linked to the major histocompatibility complex (MHC). The use of these backcross rats, typed for both MHC and the kidney alloantigen, as kidney donors to LEW rats showed that the kidney alloantigen did not induce detectable graft damage and that only the DA MHC was involved in primary graft rejection of DA kidneys by LEW rats. Immunofluorescence studies localized the antigen to the basement membrane of proximal convoluted tubules, and to some Bowman's capsules. Strain distribution studies showed that only 2 of 11 strains were negative for the allele under study; these were the LEW and AS strains. Species cross-reactivity studies showed that rabbit, dog, and human kidneys could absorb this specificity, although more weakly than DA kidney.

References

Mar 1, 1976·Transplantation·R J WilliamsG Williams
Oct 1, 1978·Transplantation·S A LobelF Milgrom
Sep 19, 1968·The New England Journal of Medicine·G M WilliamsF Milgrom
Jan 1, 1973·International Archives of Allergy and Applied Immunology·J KlassenG A Andres
Apr 1, 1972·The Journal of Experimental Medicine·M ScheidL J Old
Apr 1, 1974·The Australian Journal of Experimental Biology and Medical Science·P J Morris, W K Law
Nov 1, 1974·Transplantation·C B WilsonD L Stickel
Apr 7, 1971·Nature: New Biology·J J Van RoodW Van Vreeswijk
May 5, 1967·Science·L W Schierman, R A McBride

Citations

Jan 1, 1982·Springer Seminars in Immunopathology·J R BrentjensG A Andres
Feb 1, 1985·The Journal of Experimental Medicine·M D ClaymanE G Neilson
Mar 1, 1991·Kidney International·C B Wilson
Mar 1, 1991·Kidney International·C J KellyC M Meyers
Aug 1, 1982·Kidney International·J P CosynsJ T Harrington
Jun 1, 1982·Kidney International·L C Paul, C B Carpenter
May 1, 1989·The American Journal of Medicine·J R BrentjensG A Andres
Apr 1, 1993·Transplantation Proceedings·L C Paul
Oct 1, 1988·Medical Hypotheses·B Daunter
Dec 1, 1981·Clinical Immunology and Immunopathology·A KriegerE Günther
Apr 7, 2018·The Journal of Pastoral Care & Counseling : JPCC·Gregory Brown, Jim J W de Jong
Jan 1, 1981·Tissue Antigens·P J Morris, A Ting

Related Concepts

Autoantibodies
Graft Rejection
Isoantibodies
Alloantigens
Kidney
Kidney Tubules, Proximal
Major Histocompatibility Complex
August Rats
Transplant Recipients
Kidney Transplantation

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