Kidney transplantation using donors with history of diabetes and hypertension

Transplantation Proceedings
H H WoltersN Senninger

Abstract

Due to the persistant organ shortage for kidney transplantation, donor selection has changed in the past years. Although hypertension and diabetes mellitus are known to be risk factors for renal insufficiency, kidneys from donors with these diagnoses in their history have been accepted for kidney transplantation even with an increased risk of poor graft function. Herein we have reported our experience with kidney transplantation using grafts from donors with both, a history of type II diabetes and hypertension. Between 2000 and 2005, ten patients were grafted using donors with history of type II diabetes mellitus and hypertension. Mean donor age was 58 +/- 7.5 years and recipient age, 52.2 +/- 15.7 years. Mean HLA mismatch was 0.8 (A); 1.2 (B) and 0.9 (DR). Cold ischemia time was 17.4 +/- 4.1 hours. Immunosuppression was based on CyA (n = 7), tacrolimus (n = 2) or sirolimus (n = 1). Six patients (60%) showed good initial function, and four (40%) had delayed graft function (DGF). One patient died at ten weeks due to multiorgan failure. Two (20%) biopsy-proven rejections were diagnosed, one of which was resistant to therapy. Six months after kidney transplantation, 7 (77%, n = 9) showed good graft function (creatinine 1.3 to 2.4 ...Continue Reading

References

Jul 9, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S L NybergM D Stegall
Mar 19, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·Heiner H WoltersKarl-Heinz Dietl

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Citations

Jun 21, 2008·Advances in Chronic Kidney Disease·Sri G YarlagaddaAlkesh Jani
Dec 19, 2006·Transplantation Proceedings·S SohrabiD Talbot
Mar 14, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·S SohrabiD Talbot
Dec 29, 2020·Transplantation Proceedings·Kevin ChenAbdolreza Haririan

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