Abstract
We have previously reported successful induction of transient mixed chimerism and long-term acceptance of renal allografts in MHC mismatched nonhuman primates. In this study, we attempted to extend this tolerance induction approach to islet allografts. A total of eight recipients underwent MHC mismatched combined islet and bone marrow (BM) transplantation after induction of diabetes by streptozotocin. Three recipients were treated after a nonmyeloablative conditioning regimen that included low-dose total body and thymic irradiation, horse Atgam (ATG), six doses of anti-CD154 monoclonal antibody (mAb), and a 1-month course of cyclosporine (CyA) (Islet A). In Islet B, anti-CD8 mAb was administered in place of CyA. In Islet C, two recipients were treated with Islet B, but without ATG. The results were compared with previously reported results of eight cynomolgus monkeys that received combined kidney and BM transplantation (Kidney A) following the same conditioning regimen used in Islet A. The majority of kidney/BM recipients achieved long-term renal allograft survival after induction of transient chimerism. However, prolonged islet survival was not achieved in similarly conditioned islet/BM recipients (Islet A), despite induction ...Continue Reading
References
Dec 28, 1999·Transplantation·T KawaiA B Cosimi
Jul 31, 2001·Transplantation·T KawaiD S C Ko
Jun 27, 2002·Transplantation·Tatsuo KawaiJoren C Madsen
Dec 31, 2002·Lancet·L MobergB Nilsson
Mar 5, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M KoulmandaR N Smith
Feb 7, 2004·Cell Transplantation·John J O'NeilTatsuo Kawai
Mar 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Olaf HeiselPaul Keown
Aug 17, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Tatsuo KawaiA Benedict Cosimi
Jan 26, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·D YinA S Chong
Feb 9, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I KoyamaT Kawai
Oct 30, 2007·Nature Medicine·Chengyang LiuAli Naji
Jan 25, 2008·The New England Journal of Medicine·Tatsuo KawaiDavid H Sachs
Jul 16, 2008·Transplantation·R Neal SmithEnrico Cagliero
Jan 21, 2010·Diabetes·Francesco VendrameAlberto Pugliese
Nov 8, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Y YamadaT Kawai
Nov 10, 2011·Current Opinion in Organ Transplantation·A M James Shapiro
Mar 7, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M KoulmandaT B Strom
Apr 13, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M D BellinB J Hering
May 10, 2013·The New England Journal of Medicine·Tatsuo KawaiUNKNOWN Immune Tolerance Network
Jun 3, 2014·International Journal of Endocrinology·Mazhar A KanakBashoo Naziruddin
Jun 7, 2014·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T KawaiA B Cosimi
Sep 25, 2014·Transplantation·Camillo Ricordi
Apr 24, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M TonshoJ S Allan
Citations
Mar 19, 2016·Microsurgery·Maria SiemionowMehmet Bozkurt
Aug 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T OuraT Kawai
Jan 18, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Wiebke SommerGregor Warnecke
Feb 12, 2017·Stem Cells Translational Medicine·Esma S YolcuNadir Askenasy
Aug 23, 2019·Bone Marrow Transplantation·Megan Sykes, Adam D Griesemer
Jul 12, 2019·Science Translational Medicine·Stuart J KnechtleJoren C Madsen
Apr 9, 2020·Transplantation·Sulemon ChaudhryAdam D Griesemer
Jan 23, 2020·Scientific Reports·Geun Soo KimJae Berm Park
Aug 1, 2020·Transplantation·Sulemon ChaudhryAdam D Griesemer
Aug 4, 2019·Nature Communications·Amar SinghBernhard J Hering
Mar 5, 2021·Frontiers in Immunology·Shiva Pathak, Everett H Meyer
Jun 1, 2021·Frontiers in Endocrinology·Thomas PomposelliKazuhiko Yamada
Nov 11, 2021·Journal of Hepato-biliary-pancreatic Sciences·Mitsuhisa Takatsuki, Susumu Eguchi