Kidney Versus Islet Allograft Survival After Induction of Mixed Chimerism With Combined Donor Bone Marrow Transplantation

Cell Transplantation
T OuraTatsuo Kawai

Abstract

We have previously reported successful induction of transient mixed chimerism and long-term acceptance of renal allografts in MHC mismatched nonhuman primates. In this study, we attempted to extend this tolerance induction approach to islet allografts. A total of eight recipients underwent MHC mismatched combined islet and bone marrow (BM) transplantation after induction of diabetes by streptozotocin. Three recipients were treated after a nonmyeloablative conditioning regimen that included low-dose total body and thymic irradiation, horse Atgam (ATG), six doses of anti-CD154 monoclonal antibody (mAb), and a 1-month course of cyclosporine (CyA) (Islet A). In Islet B, anti-CD8 mAb was administered in place of CyA. In Islet C, two recipients were treated with Islet B, but without ATG. The results were compared with previously reported results of eight cynomolgus monkeys that received combined kidney and BM transplantation (Kidney A) following the same conditioning regimen used in Islet A. The majority of kidney/BM recipients achieved long-term renal allograft survival after induction of transient chimerism. However, prolonged islet survival was not achieved in similarly conditioned islet/BM recipients (Islet A), despite induction ...Continue Reading

References

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Apr 24, 2015·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M TonshoJ S Allan

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Citations

Aug 9, 2016·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·T OuraT Kawai
Jan 18, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Wiebke SommerGregor Warnecke
Feb 12, 2017·Stem Cells Translational Medicine·Esma S YolcuNadir Askenasy
Aug 23, 2019·Bone Marrow Transplantation·Megan Sykes, Adam D Griesemer
Jul 12, 2019·Science Translational Medicine·Stuart J KnechtleJoren C Madsen
Mar 5, 2021·Frontiers in Immunology·Shiva Pathak, Everett H Meyer
Nov 11, 2021·Journal of Hepato-biliary-pancreatic Sciences·Mitsuhisa Takatsuki, Susumu Eguchi

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Methods Mentioned

BETA
PCR
electrophoresis
pancreatectomy

Software Mentioned

Prism

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