Kihi-to, a herbal traditional medicine, improves Abeta(25-35)-induced memory impairment and losses of neurites and synapses.

BMC Complementary and Alternative Medicine
Chihiro TohdaEri Joyashiki

Abstract

We previously hypothesized that achievement of recovery of brain function after the injury requires the reconstruction of neuronal networks, including neurite regeneration and synapse reformation. Kihi-to is composed of twelve crude drugs, some of which have already been shown to possess neurite extension properties in our previous studies. The effect of Kihi-to on memory deficit has not been examined. Thus, the goal of the present study is to determine the in vivo and in vitro effects of Kihi-to on memory, neurite growth and synapse reconstruction. Effects of Kihi-to, a traditional Japanese-Chinese traditional medicine, on memory deficits and losses of neurites and synapses were examined using Alzheimer's disease model mice. Improvements of Abeta(25-35)-induced neuritic atrophy by Kihi-to and the mechanism were investigated in cultured cortical neurons. Administration of Kihi-to for consecutive 3 days resulted in marked improvements of Abeta(25-35)-induced impairments in memory acquisition, memory retention, and object recognition memory in mice. Immunohistochemical comparisons suggested that Kihi-to attenuated neuritic, synaptic and myelin losses in the cerebral cortex, hippocampus and striatum. Kihi-to also attenuated the ca...Continue Reading

References

Jul 1, 1990·Neurobiology of Aging·E NilssonJ O Karlsson
Feb 1, 1985·Journal of Neurochemistry·W W SchlaepferU J Zimmerman
Dec 15, 1994·Annals of the New York Academy of Sciences·R A NixonM Beermann
Mar 28, 1998·Behavioral Neuroscience·W E DeCoteau, R P Kesner
Sep 6, 2002·Journal of Molecular Neuroscience : MN·Gabriella Di RosaOttavio Arancio
Dec 25, 2002·Japanese Journal of Pharmacology·Chihiro TohdaKatsuko Komatsu
Mar 11, 2004·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Chihiro TohdaKatsuko Komatsu
Feb 4, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Mingzhong YaoChristian J Pike
Feb 16, 2005·British Journal of Pharmacology·Tomoharu KuboyamaKatsuko Komatsu
Jun 16, 2005·Neuro-Signals·Chihiro TohdaKatsuko Komatsu
Aug 27, 2005·Neurobiology of Aging·Mee-Sook SongElena I Posse de Chaves
Jun 16, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Lorena HerediaAlfredo Lorenzo
Aug 9, 2006·Behavioral Neuroscience·Jason L Rogers, Raymond P Kesner
Mar 16, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gareth R I BarkerE Clea Warburton
May 3, 2007·Expert Opinion on Pharmacotherapy·Ben Seltzer
Oct 20, 2007·Nature Reviews. Neuroscience·Larry R SquireRobert E Clark
Feb 14, 2008·Nature Reviews. Neuroscience·Chris M Bird, Neil Burgess

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Citations

Jul 28, 2009·Revista iberoamericana de micología·Carlos Illana Esteban
Jul 1, 2011·Journal of Neurosciences in Rural Practice·M Obulesu, Dowlathabad Muralidhara Rao
May 30, 2013·Journal of Ginseng Research·Ho Jae ParkJong Hoon Ryu
Oct 4, 2015·Regulatory Toxicology and Pharmacology : RTP·Mee-Young LeeHyeun-Kyoo Shin
Dec 7, 2014·Chinese Journal of Natural Medicines·N Satheesh Kumar, N Nisha
Sep 15, 2014·Journal of Ethnopharmacology·Hwayong ParkJin Yeul Ma
Dec 24, 2013·Bioorganic & Medicinal Chemistry Letters·Hong-Yan ZhangYasuhiro Tezuka
May 12, 2015·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Chihiro Tohda, Hidetoshi Watari
Jun 21, 2019·Evidence-based Complementary and Alternative Medicine : ECAM·Hidetoshi WatariChihiro Tohda
Mar 19, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Yujin ChoiJun-Hwan Lee
Jan 1, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Marjan TalebiSaeed Samarghandian

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