Kikuchi-Fujimoto disease in children: two case reports and a review of the literature

Italian Journal of Pediatrics
Mara LeliiSamantha Bosis

Abstract

Kikuchi-Fujimoto disease is a rare, idiopathic and generally self-limiting cause of lymphadenitis of unknow etiology with a low recurrence rate. The typical clinical signs are cervical lymphadenopathy, fever, and symptoms of respiratory infection, and less frequently chills, night sweats, arthralgia, rash, and weight loss. Here we describe two case reports of Kikuchi Fujimoto disease presenting in Milan within the space of a few months. The first involved the recurrence of KFD in a young boy from Sri Lanka; the second was a rare case of severe KFD complicated by HLH. Pediatricians must consider KFD in the differential diagnosis of fever of unknown origin in children, even in western countries. Although rare, recurrence and severe complications are possible. Where symptoms suggest KFD, a systematic diagnostic approach is key. Since no guidelines on the management of KFD are available, further studies should be conducted to investigate the therapeutic options and long term outcome in children.

References

Jun 1, 1990·The American Journal of Surgical Pathology·G A ChamulakB N Nathwani
Jul 1, 1989·American Journal of Clinical Pathology·F FacchettiV J Desmet
Nov 25, 2000·The Journal of Laryngology and Otology·Y J JangH J Seok
Aug 19, 2003·Journal of Korean Medical Science·Young Mi KimEun Yup Lee
Nov 17, 2004·Pediatrics·Kyung-Yil LeeByung-Churl Lee
Dec 4, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Katayoun RezaiBeverly E Sha
Mar 16, 2006·Clinical Rheumatology·Yasar KucukardaliMustafa Kaplan
Aug 9, 2006·Clinical Pediatrics·Nilgun YarisUmit Cobanoglu
Dec 11, 2007·Leukemia & Lymphoma·Ying-Wei LinMitsuhiko Nambu
Nov 16, 2010·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Chien-Yu ChengShan-Chwen Chang
Feb 5, 2011·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hao-Yuan LeeShao-Hsuan Hsia
Apr 24, 2012·Pediatric Neurology·Paola LongarettiGian Luigi Marseglia
Nov 19, 2013·Current Opinion in Otolaryngology & Head and Neck Surgery·Abby R Nolder
Apr 10, 2014·European Journal of Pediatrics·In Hyuk YooJin Han Kang
Sep 13, 2014·Otolaryngologic Clinics of North America·Tara L Rosenberg, Abby R Nolder
Apr 9, 2016·Acta Oto-laryngologica·Hidenori MarunakaYasuharu Sato

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Citations

Oct 3, 2019·Journal of Paediatrics and Child Health·Shoba N SelvanathanKoh Cheng Thoon
Mar 27, 2021·Clinical Case Reports·Kaveh JasebSaeid Sadeghian

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Methods Mentioned

BETA
biopsy
X-ray
ESR
X ray
bone marrow aspiration

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