Kill kinetics and regrowth pattern of bacteria exposed to antibiotic concentrations simulating those observed in vivo

The Journal of Antimicrobial Chemotherapy
J P GuggenbichlerP König


Antibiotic concentrations observed in vivo were simulated in an in vitro two compartment model with a dialyser interconnection. Kill kinetics and regrowth pattern of bacteria were investigated under these fluctuating antibiotic concentrations. There were large differences in the rate of reduction of viable organisms by various antibiotics not reflected in small differences in initial MIC values. Data suggested that the area under the concentration curve might be of importance in determining the antimicrobial activity of substances rather than the initial concentration. The inclusion of pharmacokinetic parameters in antimicrobial susceptibility testing might add a new dimension to the appreciation of the activity of antimicrobial substances.


Aug 1, 1989·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·J I Blenkharn, J H Darrell
Dec 23, 2009·The Journal of Antimicrobial Chemotherapy·Julia GloedeCharlotte Kloft
Jun 1, 1994·Antimicrobial Agents and Chemotherapy·M M McFarlandA Li Wan Po
Jan 26, 2002·Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy·S OhyaY Kumamoto
Jul 28, 2016·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Debasis MandalSomenath Roy

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