Kill kinetics of antimicrobial agents against Helicobacter pylori

The Journal of Antimicrobial Chemotherapy
R K FlammJ Clement

Abstract

We evaluated the activity of clarithromycin, 14-OH clarithromycin, amoxycillin, bismuth, metronidazole and ciprofloxacin against six strains of Helicobacter pylori to determine if there were differences in response to these antimicrobial agents during growth in vitro. Clarithromycin and its 14-hydroxy-metabolite exhibited an early bactericidal activity with at least a 3 log10 reduction after 2-8 incubation. Exposure to bismuth, ciprofloxacin and metronidazole resulted in a > 3 log reduction by 24 h with the greatest decrease in viability occurring between 8 and 24 h. The viable count of three strains was reduced by a 1-2 log10 after 24 h exposure to amoxycillin and by a > 3 log10 after 48 h.

Citations

Jun 25, 2013·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Carla SilvaLuisa Jordao
Apr 23, 2011·Journal of Agricultural and Food Chemistry·Pablo Gomes FerreiraIone Salgado
Mar 27, 2010·The Journal of Antibiotics·Hideki HashizumeYuzuru Akamatsu
Jan 3, 2008·Nature Reviews. Drug Discovery·Jon O LundbergMark T Gladwin
Jun 16, 2004·Nature Reviews. Microbiology·Jon O LundbergNigel Benjamin
May 1, 2010·Nutrition and Cancer·Edward MorcosJon O Lundberg
Feb 23, 2007·Journal of Zoo and Wildlife Medicine : Official Publication of the American Association of Zoo Veterinarians·Scott B Citino, Linda Munson
May 29, 2002·Proceedings of the National Academy of Sciences of the United States of America·Jed W FaheyAlain Lozniewski
May 29, 1999·Antimicrobial Agents and Chemotherapy·I J HassanM R Millar
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·N NagaharaY Ogawa
Oct 23, 1997·Antimicrobial Agents and Chemotherapy·M SörbergL E Nilsson
Sep 6, 2002·Journal of Medicinal Chemistry·Daniel CarcanagueThomas C Kühler

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Related Papers

Zentralblatt Für Bakteriologie : International Journal of Medical Microbiology
K Vogt, H Hahn
International Journal of Antimicrobial Agents
M T FeraA Focà
Antimicrobial Agents and Chemotherapy
Y Glupczynski, A Burette
© 2021 Meta ULC. All rights reserved