Kill kinetics of bacteria under fluctuating concentrations of various antibiotics. I. Description of the model

P KönigW Foisner


Traditional antimicrobial susceptibility testing uses fixed concentrations of an antibiotic over 24 hours. In order to imitate conditions closer to the actual in vivo situation we developed a model which allows us to simulate serum and tissue concentrations observed under clinical conditions in vitro. Kill kinetics and regrowth pattern of various bacteria have been investigated under the influence of different antibiotics in this kinetic model.


May 12, 2004·Diagnostic Microbiology and Infectious Disease·Sheryl A ZelenitskyRobert E Ariano
Dec 23, 2009·The Journal of Antimicrobial Chemotherapy·Julia GloedeCharlotte Kloft
Jun 1, 1994·Antimicrobial Agents and Chemotherapy·M M McFarlandA Li Wan Po
Jan 1, 1995·Antimicrobial Agents and Chemotherapy·M L BarclayD R Boswell
Jan 27, 2004·Antimicrobial Agents and Chemotherapy·Markus MuellerHartmut Derendorf
Aug 1, 1988·Journal of Pharmacokinetics and Biopharmaceutics·J G ZhiR Quintiliani

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