Killer artificial antigen-presenting cells: the synthetic embodiment of a 'guided missile'.

Immunotherapy
Christian SchützMartin Fleck

Abstract

At present, the treatment of T-cell-dependent autoimmune diseases relies exclusively on strategies leading to nonspecific suppression of the immune systems causing a substantial reduced ability to control concomitant infections or malignancies. Furthermore, long-term treatment with most drugs is accompanied by several serious adverse effects and does not consequently result in cure of the primary immunological malfunction. By contrast, antigen-specific immunotherapy offers the potential to achieve the highest therapeutic efficiency in accordance with minimal adverse effects. Therefore, several studies have been performed utilizing antigen-presenting cells specifically engineered to deplete allo- or antigen-specific T cells ('guided missiles'). Many of these strategies take advantage of the Fas/Fas ligand signaling pathway to efficiently induce antigen-presenting cell-mediated apoptosis in targeted T cells. In this article, we discuss the advantages and shortcomings of a novel non-cell-based 'killer artificial antigen-presenting cell' strategy, developed to overcome obstacles related to current cell-based approaches for the treatment of T-cell-mediated autoimmunity.

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Citations

Jul 11, 2013·Nanomedicine·Joel C Sunshine, Jordan J Green
Apr 11, 2013·Current Opinion in Immunology·Leonie E PaulisCarl G Figdor
May 6, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·James D FisherSteven R Little
Feb 24, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pau Serra, Pere Santamaria
Mar 31, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yesica GarciafigueroaNick Giannoukakis
Oct 12, 2017·PloS One·Ellen M LeitmanPhilip J R Goulder
Dec 19, 2020·Biomaterials·Ariel IsserJonathan P Schneck
Jan 23, 2018·Bioconjugate Chemistry·Yao JiangLiangfang Zhang

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