Killer cell activity and antibody-dependent cell-mediated cytotoxicity are normal in Hashimoto's disease

The Journal of Clinical Endocrinology and Metabolism
J SackK D Burman

Abstract

Antibody-dependent cell-mediated cytotoxicity (ADCC) is the process by which antibodies interact with killer cells to effect cell lysis, whereas natural killing (NK) refers to the ability of peripheral blood killer cells to lyse target cells in the absence of specific antibody. The purpose of the present study was to determine if either NK cells or ADCC might play a role in the development of Hashimoto's thyroiditis (HD) by testing the ability of killer cells to cause lysis of K562 erythroleukemia tumor cells and human thyrocytes in the presence and absence of serum from normal and HD patients. Using K562 target cells, NK activity was 70 +/- 4% (mean +/- SEM) for HD effector cells and 66 +/- 5% for normal effector cells at an effector to target ratio of 100:1. Similarly, with thyrocytes as targets, effector cells from HD patients (38 +/- 3%) and normal subjects (34 +/- 5%) caused comparable lysis (at an effector to target ratio of 100:1). Using K562 target cells, ADCC was 35% when effector cells from HD or normal subjects were coincubated with either normal or HD sera. Using thyrocyte target cells, lysis was about 25-30%, but, again, no differences were found between HD and normal effector cells or serum. There was a significan...Continue Reading

Citations

Jan 1, 1989·Immunologic Research·E GrunebaumY Shoenfeld
Aug 1, 1988·Baillière's Clinical Endocrinology and Metabolism·N Amino
Jul 17, 2001·Clinical Endocrinology·J D Bretz, J R Baker
Jan 1, 1991·Thyroid : Official Journal of the American Thyroid Association·S MatsubayashiR Volpé
Apr 1, 1992·Clinical Endocrinology·A P Weetman
Aug 1, 1987·Journal of Endocrinological Investigation·L ChiovatoA Pinchera
Feb 1, 1990·European Journal of Immunology·A P WeetmanM W Makgoba

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