Killer cell immunoglobulin-like receptor gene diversity in the Tibetan ethnic minority group of China

Human Immunology
Bo-feng ZhuZhen-Yuan Wang

Abstract

The aim of this study was to analyze killer immunoglobulin-like receptor (KIR) gene polymorphisms in the Tibetan ethnic minority of China. To that purpose, we have studied KIR gene frequencies and genotype diversities of 16 KIR genes and three pseudogenes (2DL1, 2DL2, 2DL3, 2DL4, 2DL5A, 2DL5B, 2DS1, 2DS2, 2DS3, 2DS4*001/002, 2DS4*003-007, 2DS5, 3DL1, 3DL2, 3DL3, 3DS1, 2DP1, 3DP1*001/002/004, and 3DP1*003) in a population sample of 102 unrelated healthy individuals of the Tibetan population living in Lhasa city, Tibet Autonomous Region of China. Tibetans mainly live in "the roof of the world," the Qinghai-Tibet Plateau of China and surrounding areas stretching from central Asia in the North and West to Myanmar and mainland China in the East, and India, Nepal, and Bhutan to the south. KIR gene frequencies and statistical parameters of Tibetan ethnic minority were calculated. Fifteen KIR genes were observed in the 102 tested Tibetan individuals with different frequencies. The allelic frequencies of the 15 KIR genes ranged from 0.06 to 0.86. In addition, KIR 2DL1, 2DL4, 3DL2, and 3DL3 were found to be present in every individual. Variable gene content, together with allelic polymorphisms, can result in individualized human KIR geno...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jan 16, 1998·Immunity·M UhrbergP Parham
Mar 31, 1999·Proceedings of the National Academy of Sciences of the United States of America·G A SnyderP D Sun
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J WilsonJ Trowsdale
Jun 1, 2000·Human Genetics·Y QianL Jin
Mar 21, 2002·Immunogenetics·Raja RajalingamPeter Parham
May 20, 2003·Tissue Antigens·D MiddletonR Komerofsky
Jun 6, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M A CookD C Briggs
Jul 16, 2003·Tissue Antigens·S G E MarshH Wain
Aug 5, 2003·International Journal of Hematology·Sherif S FaragMichael A Caligiuri
Nov 25, 2003·Human Immunology·Dimitra NiokouCatherine Stavropoulos-Giokas
Jan 1, 2004·Human Immunology·Fionnuala WilliamsDerek Middleton
Sep 3, 2004·Current Opinion in Immunology·Lorenzo Moretta, Alessandro Moretta
Feb 8, 2005·Human Immunology·Dong Hee WhangMyoung Hee Park
May 16, 2006·Human Immunology·M E Gutiérrez-RodríguezM Cruz
May 23, 2006·International Journal of Immunogenetics·W LuszczekP Kuśnierczyk
May 31, 2006·Immunogenetics·Marija VelickovicHeather Dunckley
Jun 2, 2006·Immunogenetics·Ketevan GendzekhadzePeter Parham
Apr 21, 2007·Tissue Antigens·P A GourraudD Middleton
May 15, 2007·Tissue Antigens·A C FloresL Fainboim
Jun 7, 2007·Immunogenetics·Paloma Daguer EwertonEduardo José Melo dos Santos
Jan 12, 2008·International Journal of Immunogenetics·Y PavlovaA Slavcev
Sep 16, 2008·Best Practice & Research. Clinical Haematology·Bartosz GrzywaczMichael R Verneris
Oct 14, 2008·Human Immunology·Cristiane Conceição Chagas RudnickJeane Eliete Laguila Visentainer

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Citations

Oct 3, 2015·Human Immunology·Pokhraj GuhaTapas Kumar Chaudhuri
Apr 13, 2011·Immunology·Alicia Sanchez-MazasErik Thorsby
Nov 4, 2016·HLA : Immune Response Genetics·L JiangQ Chen

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