Abstract
To investigate the role of the killer cell immunoglobulin-like receptor (KIR) gene's repertoire in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. KIR genotypes were determined in 122 patients with RA and 96 healthy controls by the sequence-specific primer polymerase chain reaction (SSP-PCR) method. Human leucocyte antigen (HLA)-C genotyping was also performed simultaneously in 72 patients and 66 controls by the SSP-PCR method. The total carriage frequency of KIR 2DS4 regardless of corresponding HLA-Cw4 was significantly increased in RA patients compared with controls [p<0.001, odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.4, Pc<0.01]. The total carriage frequency of KIR 2DL1 regardless of corresponding HLA-C also tended to be increased in RA patients (p<0.02, OR = 2.1, 95% CI = 1.2-3.9, Pc = not significant). The frequency of KIR 2DS4 with corresponding HLA-Cw4 was increased in RA patients in comparison with controls (p = 0.02, OR = 3.2, 95% CI = 1.1-9.4). Moreover, the association of RA with KIR 2DS4 depended on the presence of the corresponding HLA-Cw4. KIR 2DS4 may be a risk factor for susceptibility to RA in Taiwan.
References
Sep 1, 1995·The Journal of Experimental Medicine·A MorettaL Moretta
Feb 1, 1996·The Journal of Experimental Medicine·R BiassoniL Moretta
Jan 16, 1998·Immunity·M UhrbergP Parham
May 23, 1998·Annual Review of Immunology·L L Lanier
Jun 28, 2000·Circulation·G LiuzzoC M Weyand
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T NamekawaJ J Goronzy
May 23, 2001·The Journal of Experimental Medicine·J H YenJ J Goronzy
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G KatzO Mandelboim
Aug 22, 2001·Immunological Reviews·J C RyanM R Daws
Aug 22, 2001·Immunological Reviews·J TrowsdaleM J Wilson
Aug 22, 2001·Immunological Reviews·R BiassoniA Moretta
Oct 19, 2001·Mayo Clinic Proceedings·C M WeyandR L Frye
Feb 23, 2002·Molecular Immunology·Francisco BorregoJohn E Coligan
Feb 28, 2002·Annual Review of Immunology·Carlos Vilches, Peter Parham
Sep 10, 2002·Transplant Immunology·Derek MiddletonLynne Maxwell
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen P MartinMary Carrington
Nov 26, 2002·Tissue Antigens·L D MaxwellM D Curran
Dec 11, 2002·Tissue Antigens·S ChouaibA Caignard
Jun 12, 2003·American Journal of Reproductive Immunology : AJRI·Marighoula Varla-LeftheriotiCatherine Stavropoulos-Giokas
Oct 28, 2003·Transplantation·Maria Luisa VampaWilson Wong
Mar 3, 2004·Tissue Antigens·M López-BotetM Gumá
May 18, 2004·Arthritis and Rheumatism·T MomotT Witte
Citations
Jul 7, 2011·European Journal of Human Genetics : EJHG·Julia D RempelPeter Nickerson
Dec 13, 2007·Croatian Medical Journal·Lu Zhi-mingZhao Yue-ran
Dec 13, 2006·British Journal of Haematology·Zachary P NearmanJaroslaw P Maciejewski
Dec 3, 2008·International Journal of Immunogenetics·A ShastryC B Sanjeevi
May 15, 2007·Tissue Antigens·D MiddletonG D Wright
Jul 30, 2014·BMC Musculoskeletal Disorders·Edyta MajorczykPiotr Kuśnierczyk
Dec 15, 2015·PloS One·Masoumeh NazariReza Mansouri
Dec 29, 2009·Human Immunology·Timothy J WilsonRafael Roesler
Apr 24, 2014·Human Immunology·Sebastian GiebelEwa Grzybowska
Jun 10, 2014·Human Immunology·Swayam PrakashSuraksha Agrawal
Nov 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippa R KennedyAshley Moffett
Jun 7, 2007·Immunogenetics·Paloma Daguer EwertonEduardo José Melo dos Santos
Sep 21, 2007·Genes and Immunity·E MajorczykP Kuśnierczyk
Mar 15, 2008·Genes and Immunity·R D LevinsonR Rajalingam
Jul 23, 2008·Tissue Antigens·M JobimG Schwartsmann
Jan 1, 2012·Annals of Vascular Diseases·Naoyuki Tsuchiya
Mar 29, 2014·Modern Rheumatology·Dazhi FanFaming Pan
Jun 27, 2009·Annals of Neurology·Elizabeth A Trachtenberg
Oct 27, 2016·Clinical and Experimental Immunology·C M MariaselvamV S Negi
Jan 31, 2019·BMC Medical Genetics·Hamideh AghaeiMahdi Mahmoudi
Jun 14, 2019·PloS One·Suzanne SamaraniAli Ahmad
Oct 27, 2007·Scandinavian Journal of Rheumatology·C L KohemJ A B Chies
Sep 13, 2011·Diabetologia·K L MehersK M Gillespie
Oct 27, 2007·Scandinavian Journal of Rheumatology·V ChandranD D Gladman
Oct 6, 2020·Journal of Immunology Research·Fereshteh BeigmohammadiNima Rezaei
Sep 24, 2010·Oral Diseases·M CarrozzoA Amoroso
Aug 15, 2008·Tissue Antigens·K S ParkY W Song
Jul 20, 2021·Reports of Biochemistry & Molecular Biology·Bijan Ansari-MoghaddamFarhad Shahsavar