Killer cell immunoglobulin-like receptor gene's repertoire in rheumatoid arthritis

Scandinavian Journal of Rheumatology
J-H YenH-W Liu

Abstract

To investigate the role of the killer cell immunoglobulin-like receptor (KIR) gene's repertoire in the pathogenesis of rheumatoid arthritis (RA) in Taiwan. KIR genotypes were determined in 122 patients with RA and 96 healthy controls by the sequence-specific primer polymerase chain reaction (SSP-PCR) method. Human leucocyte antigen (HLA)-C genotyping was also performed simultaneously in 72 patients and 66 controls by the SSP-PCR method. The total carriage frequency of KIR 2DS4 regardless of corresponding HLA-Cw4 was significantly increased in RA patients compared with controls [p<0.001, odds ratio (OR) = 1.9, 95% confidence interval (CI) = 1.1-3.4, Pc<0.01]. The total carriage frequency of KIR 2DL1 regardless of corresponding HLA-C also tended to be increased in RA patients (p<0.02, OR = 2.1, 95% CI = 1.2-3.9, Pc = not significant). The frequency of KIR 2DS4 with corresponding HLA-Cw4 was increased in RA patients in comparison with controls (p = 0.02, OR = 3.2, 95% CI = 1.1-9.4). Moreover, the association of RA with KIR 2DS4 depended on the presence of the corresponding HLA-Cw4. KIR 2DS4 may be a risk factor for susceptibility to RA in Taiwan.

References

Jan 16, 1998·Immunity·M UhrbergP Parham
May 23, 1998·Annual Review of Immunology·L L Lanier
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·T NamekawaJ J Goronzy
Jun 8, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·G KatzO Mandelboim
Aug 22, 2001·Immunological Reviews·J TrowsdaleM J Wilson
Aug 22, 2001·Immunological Reviews·R BiassoniA Moretta
Oct 19, 2001·Mayo Clinic Proceedings·C M WeyandR L Frye
Feb 28, 2002·Annual Review of Immunology·Carlos Vilches, Peter Parham
Sep 10, 2002·Transplant Immunology·Derek MiddletonLynne Maxwell
Sep 10, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Maureen P MartinMary Carrington
Jun 12, 2003·American Journal of Reproductive Immunology : AJRI·Marighoula Varla-LeftheriotiCatherine Stavropoulos-Giokas
May 18, 2004·Arthritis and Rheumatism·T MomotT Witte

❮ Previous
Next ❯

Citations

Dec 13, 2006·British Journal of Haematology·Zachary P NearmanJaroslaw P Maciejewski
Dec 3, 2008·International Journal of Immunogenetics·A ShastryC B Sanjeevi
Nov 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Philippa R KennedyAshley Moffett
Jun 7, 2007·Immunogenetics·Paloma Daguer EwertonEduardo José Melo dos Santos
Jan 1, 2012·Annals of Vascular Diseases·Naoyuki Tsuchiya
Oct 27, 2016·Clinical and Experimental Immunology·C M MariaselvamV S Negi
Oct 27, 2007·Scandinavian Journal of Rheumatology·C L KohemJ A B Chies
Oct 27, 2007·Scandinavian Journal of Rheumatology·V ChandranD D Gladman
Oct 6, 2020·Journal of Immunology Research·Fereshteh BeigmohammadiNima Rezaei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Related Papers

Nan fang yi ke da xue xue bao = Journal of Southern Medical University
Shao-jie FuWen-feng Deng
Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA
Xiao-lin YinYang Zhao
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics
Bo JiangRi Zhang
© 2022 Meta ULC. All rights reserved