Killer-cell Immunoglobulin-like Receptor (KIR) gene profiles modify HIV disease course, not HIV acquisition in South African women

BMC Infectious Diseases
V NaranbhaiT Ndung'u

Abstract

Killer-cell Immunoglobulin-like Receptors (KIR) interact with Human Leukocyte Antigen (HLA) to modify natural killer- and T-cell function. KIR are implicated in HIV acquisition by small studies that have not been widely replicated. A role for KIR in HIV disease progression is more widely replicated and supported by functional studies. To assess the role of KIR and KIR ligands in HIV acquisition and disease course, we studied at-risk women in South Africa between 2004-2010. Logistic regression was used for nested case-control analysis of 154 women who acquired vs. 155 who did not acquire HIV, despite high exposure. Linear mixed-effects models were used for cohort analysis of 139 women followed prospectively for a median of 54 months (IQR 31-69) until 2014. Neither KIR repertoires nor HLA alleles were associated with HIV acquisition. However, KIR haplotype BB was associated with lower viral loads (-0.44 log10 copies/ml; SE = 0.18; p = 0.03) and higher CD4+ T-cell counts (+80 cells/μl; SE = 42; p = 0.04). This was largely explained by the protective effect of KIR2DL2/KIR2DS2 on the B haplotype and reciprocal detrimental effect of KIR2DL3 on the A haplotype. Although neither KIR nor HLA appear to have a role in HIV acquisition, our...Continue Reading

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Citations

Dec 9, 2016·Omics : a Journal of Integrative Biology·Kudakwashe MhandireBabill Stray-Pedersen
Mar 13, 2018·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Masahiko MoriPathom Sawanpanyalert
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Jul 16, 2016·AIDS Research and Human Retroviruses·Thaysse Cristina Neiva Ferreira LeiteMonick Lindenmeyer Guimarães

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Methods Mentioned

BETA
genotyping
PCR
flow-cytometry

Clinical Trials Mentioned

NCT01687387
NCT02252263
NCT01592370
NCT01750580
NCT01714739

Software Mentioned

rms
R
survival
lme4
LDheatmap
LOWESS
ggplot2

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