Killer cell immunoglobulin-like receptor (KIR) locus profiles in the Tunisian population

Human Immunology
Bani MeriemHmida Slama

Abstract

Killer cell immunoglobulin-like receptors (KIRs) are a family of inhibitory and activatory receptors that are expressed by most natural killer (NK) cells. The KIR gene family is polymorphic: genomic diversity is achieved through differences in gene content and allelic polymorphism. The number of KIR loci has been reported to vary among individuals, resulting in different KIR haplotypes. In this study we report the genotypic structure of KIRs in 267 unrelated and healthy Tunisian subjects by polymerase chain reaction-sequence-specific primer (PCR-SSP) method. All 16 KIR genes were observed in the population with different frequencies; framework genes KIR3DP1 and KIR3DL2 and the nonframework genes KIR2DL1 and KIR2DP1 were present in all individuals. A total of 26 different KIR gene profiles and 54 subgenotypes were observed in the tested population samples. Genotype 1, with a frequency of 36.6%, is the most commonly observed in the Tunisian population. Our results showed that the Tunisian population possesses the previously reported general features of the Caucasian as well as African populations, with some additional interesting differences. Such knowledge of the KIR gene distribution in populations is very useful in the study o...Continue Reading

References

Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M ColonnaJ L Strominger
Jan 16, 1998·Immunity·M UhrbergP Parham
Jan 29, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·H WendeA Volz
Jun 8, 1999·Annual Review of Immunology·E O Long
Apr 26, 2000·Proceedings of the National Academy of Sciences of the United States of America·M J WilsonJ Trowsdale
Mar 13, 2001·Annual Review of Immunology·D H RauletC W McMahon
Mar 21, 2002·Immunogenetics·Raja RajalingamPeter Parham
Jul 23, 2002·Nature Genetics·Maureen P MartinMary Carrington
Sep 10, 2002·Transplant Immunology·Derek MiddletonLynne Maxwell
May 20, 2003·Tissue Antigens·D MiddletonR Komerofsky
Jun 6, 2003·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M A CookD C Briggs
May 27, 2004·European Journal of Immunology·Pokrath HansasutaVeronique M Braud
Feb 8, 2005·Human Immunology·Dong Hee WhangMyoung Hee Park
Mar 31, 2006·Human Immunology·Marco Antonio Montes-CanoMaría Francisca González-Escribano
May 16, 2006·Human Immunology·M E Gutiérrez-RodríguezM Cruz
May 31, 2006·Immunogenetics·Marija VelickovicHeather Dunckley
Jun 2, 2006·Immunogenetics·Ketevan GendzekhadzePeter Parham
May 15, 2007·Tissue Antigens·A C FloresL Fainboim
Jun 7, 2007·Immunogenetics·Paloma Daguer EwertonEduardo José Melo dos Santos
Sep 11, 2007·Trends in Immunology·Jakob R PasswegEddy Roosnek
Jan 12, 2008·International Journal of Immunogenetics·Y PavlovaA Slavcev

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Citations

Mar 3, 2020·HLA : Immune Response Genetics·Chen ChenFaming Zhu

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