Killer-cell immunoglobulin-like receptors reactivity and outcome of stem cell transplant

Current Opinion in Hematology
Andrea VelardiAntonella Mancusi

Abstract

This review focuses on advances in the field of natural killer (NK) cell alloreactivity as a form of immunotherapy in the setting of allogeneic haematopoietic transplantation. Recent research has focused on mechanisms underlying the acquisition of function by NK cells after haematopoietic transplantation, on the therapeutic impact of NK-cell alloreactivity in various forms of transplantation and in adoptive immunotherapy. Finally, studies have highlighted the role of NK-cell responses in viral infections after transplantation. Donor-versus-recipient NK-cell alloreactivity is established as a key therapeutic element in human leukocyte antigen haplotype-mismatched haematopoietic transplants in adult acute myeloid leukaemia (AML) and paediatric acute lymphoblastic leukaemia (ALL). NK-cell allotherapy for leukaemia is deployed through stem cell transplantation (and ensuing NK-cell reconstitution) across killer-cell immunoglobulin-like receptor ligand mismatches. Donor-derived NK cells were also reported to respond to cytomegalovirus by acquiring features that are reminiscent of the specificity and memory of adaptive (T-cell) immune responses. As NK cells are the earliest immune cells to recover after transplant, this observation su...Continue Reading

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Citations

Mar 5, 2013·The Journal of Clinical Investigation·Ivy T TranIvan Maillard
Jun 4, 2014·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Geok Choo SimLaszlo Radvanyi
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Aug 30, 2016·The Journal of Clinical Investigation·Vanessa LandtwingChristian Münz
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Sep 18, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rafijul BariWing Leung
Dec 12, 2017·Frontiers in Immunology·Christian Münz
Apr 20, 2017·Frontiers in Immunology·Clair M Gardiner, David K Finlay
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Feb 24, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Miguel Lopez-Botet, Aura Muntasell

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