PMID: 11328295May 1, 2001Paper

Killer T-cell induction in patients with blastic natural killer cell lymphoma/leukaemia: implications for successful treatment and possible therapeutic strategies

British Journal of Haematology
O YamadaA Shibuya

Abstract

A rare form of putative natural killer (NK) cell lymphoma called blastic NK cell lymphoma appears to be clinicopathologically distinctive in showing a homogenous lymphoblast, variable expression of CD2, CD4, CD56 and TdT, negative for surface CD3, T-cell receptor antigen, CD16, CD34 and lack of association with Epstein-Barr virus (EBV). We report two patients with blastic NK cell lymphoma and describe the interesting clinical studies. The patients presented with cutaneous plaques. Both patients had adenopathy, and one had marrow involvement at presentation. Unlike in many NK and NK-like T-cell disorders, azurophilic cytoplasmic granules were absent. They expressed intermediate density CD45. In addition, the cells were positive for HLA-DR, CD2, CD4, CD56 and TdT, and negative for EBV transcripts. In spite of the advanced clinical stage, complete remission was achieved by conventional chemotherapy. After interleukin 2 expansion of tumour-infiltrating bone marrow and lymph node cells from the patients, cytotoxic T-cell lines with rearranged T-cell receptor genes were established. They showed specific killing activity against autologous tumour cells in an MHC-restricted fashion, with possible implications for treatment. In addition...Continue Reading

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Citations

Nov 7, 2007·Journal of Pediatric Hematology/oncology·Ann Veronique C EguarasMa Luz U Del Rosario
Apr 19, 2007·American Journal of Clinical Pathology·Marco Herling, Dan Jones
Jan 2, 2007·Cancer Letters·Amit W Panwalkar, James O Armitage
Sep 2, 2003·American Journal of Hematology·Michael ShapiroStephen J Schuster
Sep 18, 2003·Bone Marrow Transplantation·P ReimerM Wilhelm
Apr 16, 2005·Journal of Korean Medical Science·Yoonjung KimYoung H Ko

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