Killer toxin from several food-derived Debaryomyces hansenii strains effective against pathogenic Candida yeasts

International Journal of Food Microbiology
Nabaraj BanjaraHeather E Hallen-Adams

Abstract

Candida yeasts are the dominant fungi in the healthy human microbiome, but are well-known for causing disease following a variety of perturbations. Evaluation of fungal populations from the healthy human gut revealed a significant negative correlation between the foodborne yeast, Debaryomyces hansenii, and Candida species. D. hansenii is reported to produce killer toxins (mycocins) effective against other yeast species. In order to better understand this phenomenon, a collection of 42 D. hansenii isolates was obtained from 22 cheeses and evaluated for killer activity against Candida albicans and Candida tropicalis over a range of temperatures and pH values. Twenty three strains demonstrated killer activity against both C. albicans and C. tropicalis, which was pH- and temperature-dependent, with no killer activity observed for any strain at pH6.5 or higher, or at ≥35°C (physiological conditions in the human gastrointestinal tract). A cell-free mycocin preparation showed transient killer activity against C. albicans at 35°C and a cheese sample containing a killer D. hansenii strain demonstrated sustained killer activity against both C. albicans and C. tropicalis. Together, these observations raise the possibility that D. hansenii...Continue Reading

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Citations

Oct 3, 2019·World Journal of Microbiology & Biotechnology·Florian M FreimoserQuirico Migheli
Jul 19, 2020·Annual Review of Nutrition·William D FiersIliyan D Iliev
Aug 2, 2017·International Journal of Microbiology·Safaa A S Al-QaysiJamal Abd Al-Rahman Ibrahim
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Oct 13, 2020·Nucleic Acids Research·Jing TangFeng Zhu
Jan 12, 2021·World Journal of Microbiology & Biotechnology·Charles Y Tra BiDidier Montet

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