Killing me softly - suicidal erythrocyte death

The International Journal of Biochemistry & Cell Biology
Elisabeth LangFlorian Lang

Abstract

Similar to nucleated cells, erythrocytes may undergo suicidal death or eryptosis, which is characterized by cell shrinkage, cell membrane blebbing and cell membrane phospholipid scrambling. Eryptotic cells are removed and thus prevented from undergoing hemolysis. Eryptosis is stimulated by Ca(2+) following Ca(2+) entry through unspecific cation channels. Ca(2+) sensitivity is enhanced by ceramide, a product of acid sphingomyelinase. Eryptosis is triggered by hyperosmolarity, oxidative stress, energy depletion, hyperthermia and a wide variety of xenobiotics and endogenous substances. Eryptosis is inhibited by nitric oxide, catecholamines and a variety of further small molecules. Erythropoietin counteracts eryptosis in part by inhibiting the Ca(2+)-permeable cation channels but by the same token may foster formation of erythrocytes, which are particularly sensitive to eryptotic stimuli. Eryptosis is triggered in several clinical conditions such as iron deficiency, diabetes, renal insufficiency, myelodysplastic syndrome, phosphate depletion, sepsis, haemolytic uremic syndrome, mycoplasma infection, malaria, sickle-cell anemia, beta-thalassemia, glucose-6-phosphate dehydrogenase-(G6PD)-deficiency, hereditary spherocytosis, paroxysm...Continue Reading

References

Jul 24, 2008·Transfusion·Swapan K DasguptaPerumal Thiagarajan
Apr 7, 2009·Journal of Psychopharmacology·J P NicolayU E Lang
Aug 28, 2009·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Michael FöllerFlorian Lang
Sep 17, 2009·Glycoconjugate Journal·Sumanta BasuAbhijit Chakrabarti
Sep 30, 1947·The Journal of Experimental Medicine·H E HarrisonW S Albrink
Jan 12, 2010·Journal of Agricultural and Food Chemistry·Matthias EberhardFlorian Lang
Apr 30, 2010·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Michael FöllerFlorian Lang
May 12, 2010·European Journal of Clinical Investigation·Michael FöllerFlorian Lang
May 22, 2010·Pflügers Archiv : European journal of physiology·Elisabeth LangFlorian Lang
May 27, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Florian LangMichael Föller
Jun 1, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shefalee K BhavsarFlorian Lang
Jun 8, 2010·The Journal of Membrane Biology·Yuliya V KucherenkoFlorian Lang
Jul 16, 2010·American Journal of Physiology. Cell Physiology·Mehrdad GhashghaeiniaKamran Ghoreschi
Aug 28, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Balasaheb SiraskarFlorian Lang
Aug 28, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Diwakar BobbalaFlorian Lang
Nov 11, 2010·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Matthias EberhardFlorian Lang
Jan 12, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shefalee K BhavsarFlorian Lang
Feb 8, 2011·Toxicology·Syed M QadriFlorian Lang
Feb 18, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Mehrdad GhashghaeiniaThomas Wieder
May 18, 2011·Archives of Biochemistry and Biophysics·Kashif JilaniFlorian Lang
May 20, 2011·American Journal of Physiology. Cell Physiology·Elisabeth LangFlorian Lang
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Shefalee K BhavsarFlorian Lang
Jun 22, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Kathrin M FelderLudwig E Hoelzle
Jun 29, 2011·Journal of Agricultural and Food Chemistry·Sergios GatidisFlorian Lang
Jul 26, 2011·Journal of Cellular and Molecular Medicine·Syed M QadriFlorian Lang
Aug 9, 2011·Molecular Nutrition & Food Research·Kashif JilaniFlorian Lang
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Syed M QadriFlorian Lang
Aug 26, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Elisabeth LangFlorian Lang
Sep 20, 2011·Journal of Natural Products·Kashif JilaniFlorian Lang
Nov 15, 2011·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Adrian LupescuFlorian Lang
Dec 17, 2011·American Journal of Physiology. Cell Physiology·Oliver BorstFlorian Lang
Dec 17, 2011·Journal of Cellular Biochemistry·Daiana M VotaDaniela C Vittori
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Duc Bach NguyenIngolf Bernhardt
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Syed M QadriFlorian Lang
Dec 20, 2011·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Sergios GatidisFlorian Lang

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Citations

Mar 22, 2013·Archives of Toxicology·Kashif Jilani, Florian Lang
Mar 19, 2013·Folia Microbiologica·Miroslav Pohanka
Feb 22, 2013·Molecular BioSystems·Angelo D'AlessandroLello Zolla
Feb 26, 2013·PloS One·Majed AbedFlorian Lang
Jul 19, 2013·Toxins·Kashif JilaniFlorian Lang
Sep 13, 2013·Toxins·Adrian LupescuFlorian Lang
Oct 25, 2013·Toxins·Elisabeth LangFlorian Lang
Apr 10, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Etheresia Pretorius, Douglas B Kell
Mar 22, 2014·Toxins·Leonie FrauenfeldFlorian Lang
Dec 24, 2013·Antioxidants & Redox Signaling·Florian LangMichael Föller
Apr 20, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Majed AbedFlorian Lang
Jun 14, 2014·International Journal of Hematology·Rosi BissingerFlorian Lang
Dec 3, 2014·Toxicology and Applied Pharmacology·Itzel-Citlalli Aguilar-DoradoJosé-Víctor Calderón-Salinas
Jan 18, 2016·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Arbace OfficiosoCaterina Manna
May 28, 2015·Expert Opinion on Therapeutic Targets·Florian LangElisabeth Lang
Aug 1, 2015·Toxins·Kousi AlzoubiFlorian Lang
Apr 29, 2015·Toxins·Abaid MalikFlorian Lang
May 27, 2015·Toxins·Rosi BissingerFlorian Lang
Dec 24, 2014·Toxins·Kousi AlzoubiFlorian Lang
Dec 18, 2013·The Journal of Physiology·Florian Lang, Else K Hoffmann
May 28, 2015·Basic & Clinical Pharmacology & Toxicology·Omar AljanadiFlorian Lang
Aug 19, 2015·Basic & Clinical Pharmacology & Toxicology·Thomas PeterFlorian Lang
Jul 30, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabeth LangPhilipp A Lang
Jan 19, 2016·Pesticide Biochemistry and Physiology·Arbace OfficiosoFlorian Lang
Sep 25, 2015·International Journal for Parasitology. Drugs and Drug Resistance·Natalie Jane Spillman, Kiaran Kirk
Nov 10, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Michel PrudentNiels Lion
Jul 12, 2013·Basic & Clinical Pharmacology & Toxicology·Majed AbedFlorian Lang
Oct 30, 2013·Basic & Clinical Pharmacology & Toxicology·Gergely OswaldFlorian Lang
Aug 20, 2014·Basic & Clinical Pharmacology & Toxicology·Kousi AlzoubiFlorian Lang
Apr 11, 2014·Basic & Clinical Pharmacology & Toxicology·Rosi BissingerFlorian Lang
Apr 12, 2016·Translational Research : the Journal of Laboratory and Clinical Medicine·Yunus AlapanUmut A Gurkan
Nov 13, 2013·Basic & Clinical Pharmacology & Toxicology·Markus ArnoldFlorian Lang
Sep 25, 2015·Cell Biochemistry and Function·Maria Pagano, Caterina Faggio

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