PMID: 9553868Apr 29, 1998Paper

Killing of Fusobacterium nucleatum, Porphyromonas gingivalis and Prevotella intermedia by protegrins

Journal of Periodontal Research
K T MiyasakiR I Lehrer

Abstract

Protegrins are broad spectrum antibiotic peptides isolated from porcine leukocytes. In this study, we (i) examine the sensitivity of Gram-negative, anaerobic periodontal pathogens to synthetic protegrins; (ii) determine the relative potencies of protegrin congeners against these bacteria; and (iii) compare the potency of protegrins with other antibiotic peptides, including magainin MSI-78, tachyplesin I, cecropin P1, human defensins HNP-1-3, and clavanin A. Synthetic L- and D-enantiomers of protegrin 1 (PG-1 and D-PG-1, respectively), and L-enantiomers of protegrins 2, 3 and 5 (PG-2, PG-3 and PG-5) were tested against Fusobacterium nucleatum, and black-pigmented organisms including Porphyromonas gingivalis and Prevotella intermedia. Strains of both F. nucleatum and the black-pigmented organisms were sensitive to PG-1, and exhibited mean ED99 of 2.2-2.3 micrograms/ml and 3.4-9.9 micrograms/ml, respectively. The D-form was statistically more potent than the L-form against these oral anaerobes, and although this difference in potency is unlikely to be of decisive therapeutic significance, the D-form may be of value given ability to resist microbial and host-derived proteases. PG-1 was more potent than magainin, tachyplesin, cecrop...Continue Reading

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Citations

May 20, 1999·Biopolymers·D Andreu, L Rivas
Dec 24, 2004·Antimicrobial Agents and Chemotherapy·Charles E ShelburneDennis E Lopatin
Feb 28, 2007·Infection and Immunity·Catherine A Brissette, Sheila A Lukehart
Jun 18, 2002·Infection and Immunity·Catherine A Brissette, Sheila A Lukehart
May 1, 2002·Respiratory Research·Mark T AlbrechtNeal L Schiller
Oct 20, 2004·Oral Microbiology and Immunology·C A BrissetteS A Lukehart
Jan 10, 2006·Periodontology 2000·Zhimin Feng, Aaron Weinberg
Mar 7, 2017·Future Microbiology·Michael J Trimble, Robert Ew Hancock
Jul 31, 2009·The Journal of Biological Chemistry·Gang WeiWuyuan Lu
Nov 14, 2003·Journal of Medical Microbiology·S P ConcannonK-P Leung
Mar 17, 2012·Journal of Chemical Theory and Computation·Ricardo CaponeRatnesh Lal

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