Kindlin-2 in Sertoli cells is essential for testis development and male fertility in mice.

Cell Death & Disease
Xiaochun ChiHongquan Zhang

Abstract

Kindlin-2 is known to play important roles in the development of mesoderm-derived tissues including myocardium, smooth muscle, cartilage and blood vessels. However, nothing is known for the role of Kindlin-2 in mesoderm-derived reproductive organs. Here, we report that loss of Kindlin-2 in Sertoli cells caused severe testis hypoplasia, abnormal germ cell development and complete infertility in male mice. Functionally, loss of Kindlin-2 inhibits proliferation, increases apoptosis, impairs phagocytosis in Sertoli cells and destroyed the integration of blood-testis barrier structure in testes. Mechanistically, Kindlin-2 interacts with LATS1 and YAP, the key components of Hippo pathway. Kindlin-2 impedes LATS1 interaction with YAP, and depletion of Kindlin-2 enhances LATS1 interaction with YAP, increases YAP phosphorylation and decreases its nuclear translocation. For clinical relevance, lower Kindlin-2 expression and decreased nucleus localization of YAP was found in SCOS patients. Collectively, we demonstrated that Kindlin-2 in Sertoli cells is essential for sperm development and male reproduction.

References

May 30, 2003·Reproduction : the Official Journal of the Society for the Study of Fertility·Richard M SharpeJane S Fisher
Dec 22, 2005·Journal of Negative Results in Biomedicine·Katja M WolskiDon F Cameron
Dec 26, 2007·The Journal of Biological Chemistry·Yawei HaoXiaolong Yang
May 17, 2008·Genes & Development·Eloi MontanezReinhard Fässler
Jul 22, 2008·The Journal of Biological Chemistry·Tsutomu OkaMarius Sudol
Feb 4, 2010·International Journal of Cancer. Journal International Du Cancer·Zhengwen AnHongquan Zhang
Sep 22, 2012·Science·Benjamin E Smith, Robert E Braun
Jun 9, 2014·Science China. Life Sciences·Jun ZhanHongQuan Zhang
Dec 17, 2014·Cancer Letters·Han-xiang ZhanSan-yuan Hu
Sep 12, 2015·Endocrine Reviews·Dolores D Mruk, C Yan Cheng
Feb 6, 2016·Andrology·L R FrançaM D Griswold
Jun 15, 2016·Results and Problems in Cell Differentiation·Katarzyna ChojnackaDolores D Mruk
Sep 16, 2017·The Journal of Cell Biology·Ralph T BöttcherReinhard Fässler
Jan 10, 2018·Current Opinion in Cell Biology·Vivian FuKun-Liang Guan
Mar 3, 2018·The Journal of Cell Biology·Ling GuoChuanyue Wu
Aug 3, 2018·The Open Biochemistry Journal·Manjeet Kaur Gill-Sharma
Nov 22, 2018·Science China. Life Sciences·Bing LiHongquan Zhang
Dec 12, 2019·Cell Reports·Jiagui SongHongquan Zhang
Jun 3, 2020·Theranostics·Xiaokun HeHongquan Zhang

❮ Previous
Next ❯

Software Mentioned

Image Processing and Analysis Java Image J
GraphPad Prism
GraphPad
Database for Annotation , Visualization and Integrated Discove...

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.