Kindling-induced hippocampal cell death in rats.

Neuroscience and Behavioral Physiology
T A BolkvadzeL R Chilachava

Abstract

Quantitative analysis of the main cells and interneurons in different layers and fields of Ammon's horn, the hilus, and dentate gyrus was performed two weeks and one month after kindling, i.e., specific electrical stimulation of the ventral hippocampus. At both experimental time points, cells numbers were significantly decreased at all levels of the areas studied except the marginal layer of field CA4. Thus, in this model of experimental epilepsy, the process of epileptogenesis involved both interneurons and main cells in the hippocampus. The possible reorganization of intrahippocampal circuits and their involvement in the increased excitability characteristic of epilepsy are discussed.

References

Mar 11, 1999·Current Opinion in Neurobiology·S Temple, A Alvarez-Buylla
Jul 6, 2000·Nature·S S MagaviJ D Macklis
Aug 6, 2002·Nature Medicine·Andreas ArvidssonOlle Lindvall
Dec 9, 2003·Proceedings of the National Academy of Sciences of the United States of America·Kunlin JinDavid A Greenberg

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