Kindling induces a long-lasting increase in brain nitric oxide synthase activity

Neuroreport
W M al-GhoulR S Greenwood

Abstract

Generalized seizures induced by kindling are associated with a long-term increase in vasopressin mRNA expression in vasopressin neuroendocrine cells. Since nitric oxide synthase activity is strongly expressed in these neurons and may play a role in mechanisms of plasticity, we used NADPH-diaphorase histochemistry to examine nitric oxide synthase activity 1 month after amygdala kindling. Both the number of stained neurons and average intensity of cellular labeling in the supraoptic nucleus were increased in the kindled rats. In adjacent limbic regions, terminal-like staining was also increased, suggesting a general elevation of limbic nitric oxide synthase activity. Thus, increased nitric oxide production may play a role in sustaining the increase in vasopressin mRNA and plastic changes in the amygdala associated with kindling.

Citations

Oct 7, 1996·Brain Research·L SandirasegaraneP V Sulakhe
Apr 20, 2000·European Journal of Pharmacology·G De SarroA De Sarro
Nov 7, 1998·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·T GeishauserM Schemann
Oct 29, 2000·Epilepsia·T González-HernándezL González-Feria
Jun 1, 1997·Canadian Journal of Physiology and Pharmacology·J LongmoreR J Hargreaves
Jan 1, 1997·Nitric Oxide : Biology and Chemistry·E TalaveraM Condés-Lara

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