Kinematic analysis of patients with spinal muscular atrophy during spontaneous breathing and mechanical ventilation

American Journal of Physical Medicine & Rehabilitation
A LissoniJ R Bach

Abstract

Patients with infantile spinal muscular atrophy develop pectus excavatum along with a severe restrictive syndrome as a result of failure to expand the upper chest wall and lungs because of intercostal muscle weakness. By using an automatic motion analyzer to provide three-dimensional computer analyses of images sampled at 25 Hz, 9 spinal muscular atrophy Type II patients and 13 controls underwent kinematic analysis of thoracoabdominal movements partitioned into the upper thorax, lower thorax, and abdominal volume compartments. The analyses were performed during spontaneous breathing for the controls and during spontaneous breathing and while using mechanically assisted ventilation for the patients. Vital capacity, maximum inspiratory pressures, and nocturnal oxyhemoglobin saturation and transcutaneous carbon dioxide tensions were also measured for the patients. The kinematic data demonstrated a paradoxical ventilatory pattern for the spontaneously breathing SMA patients with the following inspiratory volume changes: upper thorax, -6.4+/-9.6%; lower thorax, 7.3+/-15.8%; abdominal, 99.1+/-21.3%. During mechanical ventilation, the compartmental volume changes were as follows: upper thorax, 13.5+/-6%; lower thorax, 13.7+/-7.9%; abd...Continue Reading

References

Dec 1, 1989·The Journal of Pediatrics·I S GilgoffT G Keens
Oct 1, 1986·Italian Journal of Neurological Sciences·A Lissoni, F Molteni
Nov 1, 1985·IEEE Transactions on Bio-medical Engineering·G Ferrigno, A Pedotti
Mar 1, 1995·Archives of Physical Medicine and Rehabilitation·J R Bach, T G Wang
Sep 1, 1994·Journal of Applied Physiology·G FerrignoA Pedotti
Oct 1, 1993·Italian Journal of Neurological Sciences·R ManniA Tartara
Sep 1, 1996·American Journal of Physical Medicine & Rehabilitation·A LissoniJ R Bach
Dec 1, 1996·Journal of Applied Physiology·S J CalaD F Rochester
Jun 1, 1964·The Journal of Clinical Investigation·Y ENSONR M HARVEY

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Citations

Jul 1, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Brigitte Fauroux, Sonia Khirani
Mar 25, 2017·Journal of Applied Biomechanics·Carlo MassaroniSergio Silvestri
Mar 8, 2020·The American Journal of Clinical Nutrition·Simona BertoliAlberto Battezzati
Jun 29, 2021·Annals of the American Thoracic Society·Mohammed M AlBalawiJoanna E MacLean

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