Kinematic analysis of the gait of adult sheep during treadmill locomotion: Parameter values, allowable total error, and potential for use in evaluating spinal cord injury

Journal of the Neurological Sciences
Sina SafayiMatthew A Howard

Abstract

We are developing a novel intradural spinal cord (SC) stimulator designed to improve the treatment of intractable pain and the sequelae of SC injury. In-vivo ovine models of neuropathic pain and moderate SC injury are being implemented for pre-clinical evaluations of this device, to be carried out via gait analysis before and after induction of the relevant condition. We extend previous studies on other quadrupeds to extract the three-dimensional kinematics of the limbs over the gait cycle of sheep walking on a treadmill. Quantitative measures of thoracic and pelvic limb movements were obtained from 17 animals. We calculated the total-error values to define the analytical performance of our motion capture system for these kinematic variables. The post- vs. pre-injury time delay between contralateral thoracic and pelvic-limb steps for normal and SC-injured sheep increased by ~24s over 100 steps. The pelvic limb hoof velocity during swing phase decreased, while range of pelvic hoof elevation and distance between lateral pelvic hoof placements increased after SC injury. The kinematics measures in a single SC-injured sheep can be objectively defined as changed from the corresponding pre-injury values, implying utility of this metho...Continue Reading

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Citations

Jan 20, 2016·Journal of Medical Engineering & Technology·S SafayiM A Howard
Aug 12, 2016·PloS One·Gustavo R D BernardinaAmanda P Silvatti
Oct 21, 2016·The Journal of Spinal Cord Medicine·Saul WilsonMatthew A Howard
Jan 12, 2019·Neuromodulation : Journal of the International Neuromodulation Society·Sean J NagelSaul Wilson
Nov 1, 2018·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·S WilsonM A Howard
Jul 16, 2019·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·S WilsonM A Howard
Mar 26, 2019·Journal of Neurotrauma·Sandy R ShultzRichelle Mychasiuk
Apr 4, 2019·Frontiers in Neuroscience·David J AndersonSaul Wilson
Jul 2, 2020·Journal of Neurotrauma·Maxwell BoakyeDena R Howland
May 1, 2021·Animals : an Open Access Journal From MDPI·Alison SmallIan Colditz

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