Kinematic angular parameters in PD: reliability of joint angle curves and comparison with healthy subjects

Gait & Posture
Arnaud DelvalA Duhamel

Abstract

Most previous biomechanical studies of Parkinson's disease (PD) have been restricted to the description of spatiotemporal parameters and certain peak values for angular parameters. The reliability of joint angle curves and comparisons with control data are of major interest in PD, since variability in gait cycle timing is a feature of this pathology. We used a video motion analysis system to record kinematic, spatiotemporal and angular parameters in 32 'off-drug' PD patients. The reliability of the patients' lower limb joint angle curves in the sagittal plane were analysed using the intra-class correlation coefficient (ICC), together with fast Fourier transform (FFT) analysis and hierarchical classification for discarding deviant curves. Lastly, we compared average curves (using a mixed model and the bootstrap method) for the less-affected and more-affected sides of PD patients and then compared the patient data with the results from 30 age-matched controls. The ICC-based procedure was easily applicable. Only 9.4% and 12.5% of the patients' hip and knee curves (respectively) were deemed to be unreliable. However, the PD patients' very high cycle-to-cycle variability in the sagittal plane ankle curves prevented us from applying ...Continue Reading

References

Aug 1, 1990·Journal of the Neurological Sciences·O BlinG Serratrice
Jan 1, 1972·Brain : a Journal of Neurology·E Knutsson
Oct 1, 1994·Brain : a Journal of Neurology·M E MorrisJ J Summers
Sep 27, 2000·Brain : a Journal of Neurology·G N LewisS E Walt
Jun 27, 2001·Neurology·N GiladiUNKNOWN Parkinson Study Group
Sep 1, 2004·Gait & Posture·A DuhamelL Defebvre
Sep 5, 2007·Gait & Posture·Hyun Gu Kang, Jonathan B Dingwell

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Citations

Dec 14, 2011·Journal of Neuroengineering and Rehabilitation·Timothy A ThrasherStanley Fisher
Jul 27, 2010·Journal of Biomechanics·Can A YucesoyMustafa Karahan
Aug 16, 2014·BioMed Research International·M IosaA Cappozzo
Feb 18, 2014·Journal of Biomechanics·B KoopmanH van der Kooij
Jun 18, 2016·Frontiers in Neurology·Rachel L WrightAlan M Wing
Jun 4, 2016·PloS One·Mariangela DipaolaIoannis U Isaias
Oct 14, 2017·Journal of Motor Behavior·Juan López-PascualPilar Serra-Añó
Mar 5, 2020·Journal of Geriatric Psychiatry and Neurology·Chorong OhJulie A G Stierwalt

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