Kinematic gait deficits at the trunk and pelvis: characteristic features in children with hereditary spastic paraplegia

Developmental Medicine and Child Neurology
Brooke AdairMeg E Morris

Abstract

To examine the kinematic gait deviations at the trunk and pelvis of children with hereditary spastic paraplegia (HSP). This exploratory observational study quantified gait kinematics for the trunk and pelvis from 11 children with HSP (7 males, 4 females) using the Gait Profile Score and Gait Variable Scores (GVS), and compared the kinematics to data from children with typical development using a Mann-Whitney U test. Children with HSP (median age 11y 4mo, interquartile range 4y) demonstrated large deviations in the GVS for the trunk and pelvis in the sagittal and coronal planes when compared to the gait patterns of children with typical development (p=0.010-0.020). Specific deviations included increased range of movement for the trunk in the coronal plane and increased excursion of the trunk and pelvis in the sagittal plane. In the transverse plane, children with HSP demonstrated later peaks in posterior pelvic rotation. The kinematic gait deviations identified in this study raise questions about the contribution of muscle weakness in HSP. Further research is warranted to determine contributing factors for gait dysfunction in HSP, especially the relative influence of spasticity and weakness.

References

Nov 1, 1985·The Journal of Bone and Joint Surgery. British Volume·P Hardcastle, S Nade
May 30, 2001·Pediatric Neurology·M del ToroM Roig
Dec 23, 2004·Journal of Pediatric Orthopedics·Rajan T GuptaLuciano S Dias
Feb 14, 2006·Current Neurology and Neuroscience Reports·John K Fink
Apr 7, 2007·Journal of Pediatric Orthopedics. Part B·Jacqueline RomkesReinald Brunner
May 10, 2008·Journal of Biomechanics·Michael H SchwartzJoyce P Trost
Jul 28, 2009·Gait & Posture·Richard BakerOren Tirosh
Jul 16, 2010·Gait & Posture·Julie StebbinsTim Theologis
Sep 11, 2010·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Luigi PiccininiManuela Galli
Jan 10, 2012·Gait & Posture·Richard BakerH Kerr Graham
Jan 17, 2014·Journal of Children's Orthopaedics·Tim Theologis
Sep 15, 2014·European Journal of Paediatric Neurology : EJPN : Official Journal of the European Paediatric Neurology Society·Stéphane ArmandGeraldo De Coulon
Dec 7, 2014·Clinical Biomechanics·Michael AttiasStéphane Armand

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Physiotherapy Research International : the Journal for Researchers and Clinicians in Physical Therapy
D Richardson, A J Thompson
Nō to shinkei = Brain and nerve
Hiroya Utsumi, Tatsuhiko Yuasa
Nihon rinsho. Japanese journal of clinical medicine
Takefumi Kanda, Hisashi Kobayashi
Yonsei Medical Journal
I S ChoiK W Kim
Southern Medical Journal
F J FUNK
© 2022 Meta ULC. All rights reserved