Kinesin-1 plays a role in transport of SNAP-25 to the plasma membrane

Biochemical and Biophysical Research Communications
April M MortonRussell J Diefenbach

Abstract

The cellular molecular motor kinesin-1 mediates the microtubule-dependent transport of a range of cargo. We have previously identified an interaction between the cargo-binding domain of kinesin-1 heavy chain KIF5B and the membrane-associated SNARE proteins SNAP-25 and SNAP-23. In this study we further defined the minimal SNAP-25 binding domain in KIF5B to residues 874-894. Overexpression of a fragment of KIF5B (residues 594-910) resulted in significant colocalization with SNAP-25 with resulting blockage of the trafficking of SNAP-25 to the periphery of cells. This indicates that kinesin-1 facilitates the transport of SNAP-25 containing vesicles as a prerequisite to SNAP-25 driven membrane fusion events.

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Citations

Apr 3, 2012·Neurogenetics·Kathrin N KarleLudger Schöls
Feb 9, 2013·Current Opinion in Biotechnology·Chenbo Dong, Cerasela Zoica Dinu
Sep 27, 2012·The International Journal of Biochemistry & Cell Biology·Yingjie WangYongjun Wang
Sep 1, 2015·Frontiers in Molecular Neuroscience·Josta T Kevenaar, Casper C Hoogenraad
Apr 10, 2021·Virology·Grayson DuRaine, David C Johnson

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