PMID: 10637314Jan 19, 2000

Kinetic analysis of a molecular model of the budding yeast cell cycle

Molecular Biology of the Cell
K C ChenJ J Tyson

Abstract

The molecular machinery of cell cycle control is known in more detail for budding yeast, Saccharomyces cerevisiae, than for any other eukaryotic organism. In recent years, many elegant experiments on budding yeast have dissected the roles of cyclin molecules (Cln1-3 and Clb1-6) in coordinating the events of DNA synthesis, bud emergence, spindle formation, nuclear division, and cell separation. These experimental clues suggest a mechanism for the principal molecular interactions controlling cyclin synthesis and degradation. Using standard techniques of biochemical kinetics, we convert the mechanism into a set of differential equations, which describe the time courses of three major classes of cyclin-dependent kinase activities. Model in hand, we examine the molecular events controlling "Start" (the commitment step to a new round of chromosome replication, bud formation, and mitosis) and "Finish" (the transition from metaphase to anaphase, when sister chromatids are pulled apart and the bud separates from the mother cell) in wild-type cells and 50 mutants. The model accounts for many details of the physiology, biochemistry, and genetics of cell cycle control in budding yeast.

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Related Concepts

Saccharomyces cerevisiae Proteins
Cyclin-Dependent Kinase Inhibitor Proteins
CLB2
CLB5
Cyclin-Dependent Kinases
PPT1 gene
Gene Dosage
CLB2 protein, S cerevisiae
BCK2 protein, S cerevisiae
Saccharomyces cerevisiae allergenic extract

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